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MAP3K14 [cytosol]
Stable Identifier
R-BTA-168189
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
E1BL08
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
p-S400-Cot phosphorylates NIK (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
TNFR2 non-canonical NF-kB pathway (Bos taurus)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Bos taurus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Bos taurus)
K48polyUb-TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
NIK-->noncanonical NF-kB signaling (Bos taurus)
Activation of NIK (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
NIK autophosphorylates on T559 (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Protesomal degradation of K48polyUb-TRAF3 (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Bos taurus)
K48polyUb-TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Bos taurus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Bos taurus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Bos taurus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Bos taurus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAF3 binds BAFFR:BAFF (Bos taurus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAFs bind RANK:RANKL (Bos taurus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Bos taurus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
TRAF3:NIK binds TRAF2:cIAP1/2 (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Bos taurus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Bos taurus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Bos taurus)
TRAF3:NIK [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
Dectin-1 mediated noncanonical NF-kB signaling (Bos taurus)
Activation of NIK (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
MAP3K14 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BL08
Reference Genes
BioGPS Gene:508367
ENSEMBL:ENSBTAG00000007084.6
KEGG Gene (Bos taurus):508367
Monarch:508367
NCBI Gene:508367
Reference Transcript
RefSeq:NM_001192178.1
RefSeq:XM_005220830.3
Other Identifiers
508367
GO:0000165
GO:0000166
GO:0001650
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004704
GO:0004709
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006468
GO:0006955
GO:0007249
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0036211
GO:0038061
GO:0043226
GO:0043231
GO:0051607
GO:0071260
GO:0098542
GO:0098772
GO:0140096
Participates
as an input of
NIK autophosphorylates on T559 (Bos taurus)
p-S400-Cot phosphorylates NIK (Bos taurus)
Activation of NIK (Bos taurus)
Active NIK phosphorylates IKKA dimer (Bos taurus)
as an output of
Activation of NIK (Bos taurus)
Protesomal degradation of K48polyUb-TRAF3 (Bos taurus)
as a component of
TRAF3:NIK [cytosol] (Bos taurus)
K48polyUb-TRAF3:NIK [cytosol] (Bos taurus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Bos taurus)
Other forms of this molecule
phospho-p-T559-MAP3K14 [cytosol]
K48polyUb-NIK [cytosol]
phospho-p-MAP3K14 [cytosol]
Inferred From
MAP3K14 [cytosol]
(Homo sapiens)
Active NIK [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005220887.1
,
NP_001179107.1
Ensembl
ENSBTAG00000007084
,
ENSBTAP00000009316
,
ENSBTAT00000009316
VGNC
31192
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