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RIPK1 [cytosol]
Stable Identifier
R-BTA-168651
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
RIPK1, Q3SZK6
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
IKK complex recruitment mediated by RIP1 (Bos taurus)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Bos taurus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Bos taurus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRIF-mediated programmed cell death (Bos taurus)
Caspase-8 processing within TLR4 complex (Bos taurus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIP3 binds TRIF to mediate necroptosis (Bos taurus)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Bos taurus)
RIP3:RIP1:TICAM1:activated TLR4 [endosome membrane] (Bos taurus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRIF:activated TLR4 [endosome membrane] (Bos taurus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TLR4-induced ripoptosome assembly (Bos taurus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ovarian tumor domain proteases (Bos taurus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)
TNFAIP3:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNFAIP3 (A20) ubiquitinates RIPK1 (Bos taurus)
TNFAIP3:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
Ub-specific processing proteases (Bos taurus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)
USP21:RIPK1,DDX58 [cytosol] (Bos taurus)
RIPK1, DDX58 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Caspase activation via extrinsic apoptotic signalling pathway (Bos taurus)
Caspase activation via Death Receptors in the presence of ligand (Bos taurus)
Caspase-8 processing within TLR4 complex (Bos taurus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
Dimerization of procaspase-8 (Bos taurus)
TNF-mediated dimerization of procaspase-8 (Bos taurus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
Regulation by c-FLIP (Bos taurus)
Caspase-8 and FLIP(L) processing at DISC (Bos taurus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
Regulated Necrosis (Bos taurus)
RIPK1-mediated regulated necrosis (Bos taurus)
RIPK1 is phosphorylated (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1:RIPK3 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Bos taurus)
RIPK1:RIPK3 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK3 is phosphorylated (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1:RIPK3 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Bos taurus)
RIPK1:RIPK3 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
Regulation of necroptotic cell death (Bos taurus)
CASP8 activity is inhibited (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
FLIP(S) and procaspase-8 form heterodimer (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Bos taurus)
DISC:procaspase-8 [plasma membrane] (Bos taurus)
DISC [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1 is cleaved by CASP8 (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
Small molecule inhibitor binds RIPK1, RIPK3 (Bos taurus)
RIPK1:RIPK3 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Bos taurus)
RIPK1:RIPK3 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Bos taurus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
K63polyUb-RIPK1 is deubiquitinated (Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
MAPKAPK2 phosphorylates RIPK1 at S320 (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1 binds STUB1 (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1 is cleaved by CASP8 (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1 is cleaved by CASP8:FLIP(L) (Bos taurus)
TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Bos taurus)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Bos taurus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Bos taurus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
ULK1 phosphorylates RIPK1 at S357 (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNFR1-induced NF-kappa-B signaling pathway (Bos taurus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TNFR1-induced proapoptotic signaling (Bos taurus)
TRADD:TRAF2:RIP1 binds FADD (Bos taurus)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q3SZK6
Gene Names
RIPK1
Reference Genes
BioGPS Gene:504727 RIPK1
ENSEMBL:ENSBTAG00000006378.4
KEGG:bta:504727 RIPK1
Monarch:504727 RIPK1
NCBI Gene:504727 RIPK1
UCSC:Q3SZK6 RIPK1
Reference Transcript
RefSeq:XM_005223844.3 RIPK1
RefSeq:NM_001035012.1 RIPK1
RefSeq:XM_005223843.2 RIPK1
Participates
as a component of
TNFAIP3:RIPK1 [cytosol] (Bos taurus)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Bos taurus)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
TRAF2:TRADD:RIPK1 [cytosol] (Bos taurus)
RIPK1:RIPK3 [cytosol] (Bos taurus)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Bos taurus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Bos taurus)
as a member of
RIPK1, DDX58 [cytosol] (Bos taurus)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Bos taurus)
as an input of
RIPK1 binds STUB1 (Bos taurus)
TRAF1 binds TRAF2 within TNFR1 signaling complex (Bos taurus)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Bos taurus)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Bos taurus)
Other forms of this molecule
RIPK1 [cytosol]
RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
RIPK1 [cytosol]
Inferred From
RIPK1 [cytosol]
(Homo sapiens)
Cross References
VGNC
33981
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