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SYT1 [plasma membrane]
Stable Identifier
R-BTA-168786
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
P48018
Locations in the PathwayBrowser
Expand all
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter release cycle (Bos taurus)
Acetylcholine Neurotransmitter Release Cycle (Bos taurus)
Release of acetylcholine at the synapse (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
Dopamine Neurotransmitter Release Cycle (Bos taurus)
Release of docked dopamine loaded synaptic vesicle (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
GABA synthesis, release, reuptake and degradation (Bos taurus)
Release of GABA at the synapse (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
Glutamate Neurotransmitter Release Cycle (Bos taurus)
Release of L-Glutamate at the synapse (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
Norepinephrine Neurotransmitter Release Cycle (Bos taurus)
Release of noradrenaline at the synapse (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
Serotonin Neurotransmitter Release Cycle (Bos taurus)
Release of docked serotonin loaded synaptic vesicle (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
BAR domain proteins recruit dynamin (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
STON2 binds SYT proteins (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
Clathrin recruits PIK3C2A (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
STON2,1:SYT dimers [plasma membrane] (Bos taurus)
SYT dimers [plasma membrane] (Bos taurus)
SYT1 dimer [plasma membrane] (Bos taurus)
SYT1 [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:P48018 SYT1
Gene Names
SYT1
Chain
chain:1-422
Reference Genes
BioGPS Gene:281511 SYT1
KEGG:bta:281511 SYT1
Monarch:281511 SYT1
NCBI Gene:281511 SYT1
UCSC:P48018 SYT1
Reference Transcript
RefSeq:XM_005206030.3 SYT1
RefSeq:NM_174192.3 SYT1
Other Identifiers
281511
GO:0005509
GO:0005544
GO:0005737
GO:0005794
GO:0007269
GO:0008021
GO:0008289
GO:0014059
GO:0016020
GO:0016050
GO:0016079
GO:0016192
GO:0017075
GO:0017158
GO:0030141
GO:0030424
GO:0030672
GO:0031045
GO:0031410
GO:0042584
GO:0042734
GO:0043005
GO:0043226
GO:0045202
GO:0046872
GO:0048306
GO:0048791
GO:0050750
GO:0050806
GO:0051966
GO:0061669
GO:0061891
GO:0071911
GO:0098746
GO:0098978
GO:0099502
GO:0140299
GO:1903235
GO:1903861
Participates
as a component of
SYT1 dimer [plasma membrane] (Bos taurus)
as an output of
Release of docked dopamine loaded synaptic vesicle (Bos taurus)
Release of acetylcholine at the synapse (Bos taurus)
Release of noradrenaline at the synapse (Bos taurus)
Release of L-Glutamate at the synapse (Bos taurus)
Release of GABA at the synapse (Bos taurus)
Release of docked serotonin loaded synaptic vesicle (Bos taurus)
Other forms of this molecule
SYT1 [clathrin-coated endocytic vesicle membrane]
SYT1 [synaptic vesicle membrane]
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
Inferred From
SYT1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_005206087.1
,
NP_776617.1
ENSEMBL
ENSBTAG00000034693
,
ENSBTAT00000008338
,
ENSBTAP00000008338
VGNC
35535
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