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SMAD4 [cytosol]
Stable Identifier
R-BTA-170862
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
SMAD4, B0JYL0
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Signaling by NODAL (Bos taurus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
WWTR1:SMAD translocates to the nucleus (Bos taurus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ub-specific processing proteases (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by Activin (Bos taurus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
Signaling by BMP (Bos taurus)
Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Bos taurus)
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
WWTR1:SMAD translocates to the nucleus (Bos taurus)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2,3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
SMAD4 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:B0JYL0
Gene Names
SMAD4
Reference Genes
BioGPS Gene:540248 SMAD4
ENSEMBL:ENSBTAG00000006919.4
Monarch:540248 SMAD4
NCBI Gene:540248 SMAD4
UCSC:B0JYL0 SMAD4
Reference Transcript
RefSeq:XM_005224250.2 SMAD4
Other Identifiers
540248
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001222
GO:0001223
GO:0001228
GO:0001541
GO:0001658
GO:0001666
GO:0001701
GO:0001702
GO:0001822
GO:0001837
GO:0003148
GO:0003190
GO:0003198
GO:0003220
GO:0003251
GO:0003279
GO:0003360
GO:0003677
GO:0003682
GO:0003700
GO:0005518
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006879
GO:0007179
GO:0007283
GO:0007338
GO:0007369
GO:0007411
GO:0007492
GO:0007498
GO:0008283
GO:0008285
GO:0008584
GO:0008585
GO:0009653
GO:0009952
GO:0010614
GO:0010628
GO:0010631
GO:0010718
GO:0014033
GO:0022414
GO:0030154
GO:0030308
GO:0030509
GO:0030511
GO:0032444
GO:0032525
GO:0032909
GO:0033686
GO:0035556
GO:0036302
GO:0042118
GO:0042127
GO:0042733
GO:0042802
GO:0042803
GO:0043199
GO:0043226
GO:0043565
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0046881
GO:0048382
GO:0048589
GO:0048663
GO:0048665
GO:0048729
GO:0048733
GO:0048856
GO:0048859
GO:0048870
GO:0051797
GO:0060065
GO:0060391
GO:0060395
GO:0060412
GO:0060956
GO:0061040
GO:0061629
GO:0062009
GO:0070102
GO:0070373
GO:0070411
GO:0070412
GO:0071141
GO:0071144
GO:0071559
GO:0071560
GO:0072133
GO:0072134
GO:0072520
GO:0090090
GO:0090575
GO:0097191
GO:0140110
GO:1901203
GO:1902895
GO:1905305
Participates
as an input of
Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Bos taurus)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Bos taurus)
as a component of
p-2S-SMAD1/5/8:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Bos taurus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [cytosol] (Bos taurus)
as an output of
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
Other forms of this molecule
phospho-SMAD4 [nucleoplasm]
SMAD4 [nucleoplasm]
SMAD4 [cytosol]
SMAD4 [nucleoplasm]
Inferred From
SMAD4 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005224307.1
ENSEMBL
ENSBTAT00000009081
,
ENSBTAP00000009081
VGNC
34977
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