Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDC27 [cytosol]
Stable Identifier
R-BTA-174073
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
CDC27, A7Z061
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
Mitotic Spindle Checkpoint (Bos taurus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Bos taurus)
Inactivation of APC/C via direct inhibition of the APC/C complex (Bos taurus)
Binding of the MCC complex to the APC/C complex (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Separation of Sister Chromatids (Bos taurus)
Association of Securin with Cdc20:APC/C complex (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Degradation of multiubiquitinated Securin (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)
CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Bos taurus)
Association of cell cycle proteins with the APC/C:Cdh1 complex (Bos taurus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Degradation of multiubiquitinated cell cycle proteins (Bos taurus)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Bos taurus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Bos taurus)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
APC/C:Cdc20 mediated degradation of Cyclin B (Bos taurus)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Degradation of multiubiquitinated Cyclin B (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Bos taurus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Bos taurus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Bos taurus)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
APC/C:Cdc20 mediated degradation of Securin (Bos taurus)
Association of Securin with Cdc20:APC/C complex (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Degradation of multiubiquitinated Securin (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Bos taurus)
CDC20:p-APC/C:PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Bos taurus)
APC-Cdc20 mediated degradation of Nek2A (Bos taurus)
Association of Nek2A with MCC:APC/C (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Degradation of multiubiquitinated Nek2A (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Multiubiquitinated Nek2A [cytosol] (Bos taurus)
Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Multiubiquitination of Nek2A (Bos taurus)
Multiubiquitinated Nek2A [cytosol] (Bos taurus)
Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Nek2A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Bos taurus)
Association of Cyclin A with the APC/C (Bos taurus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Degradation multiubiquitinated Cyclin A (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Bos taurus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Bos taurus)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Bos taurus)
Association of Cdh1 with the APC/C (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Dissociation of Cdc20 from APC/C complex (Bos taurus)
CDC20:p-APC/C [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Regulation of APC/C activators between G1/S and early anaphase (Bos taurus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Bos taurus)
Inactivation of APC/C via direct inhibition of the APC/C complex (Bos taurus)
Binding of the MCC complex to the APC/C complex (Bos taurus)
MCC:APC/C complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
S Phase (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
DNA Replication (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)
phospho-APC/C:Cdh1 complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
APC/C E3 ligase complex [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
APC/C E3 ligase complex [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
APC/C E3 ligase complex [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
APC/C E3 ligase complex [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
APC/C E3 ligase complex [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
APC/C E3 ligase complex [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
APC/C E3 ligase complex [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
APC/C E3 ligase complex [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
APC/C E3 ligase complex [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
APC/C E3 ligase complex [cytosol] (Bos taurus)
CDC27 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A7Z061
Gene Names
CDC27
Reference Genes
BioGPS Gene:540660 CDC27
ENSEMBL:ENSBTAG00000002726
KEGG:bta:540660 CDC27
Monarch:540660 CDC27
NCBI Gene:540660 CDC27
UCSC:A7Z061 CDC27
Reference Transcript
RefSeq:NM_001105428.1 CDC27
Participates
as a component of
APC/C E3 ligase complex [cytosol] (Bos taurus)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Bos taurus)
Other forms of this molecule
CDC27 [nucleoplasm]
Inferred From
CDC27 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001098898.1
VGNC
50040
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
