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APOA1 [extracellular region]
Stable Identifier
R-BTA-174720
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
extracellular region
Synonyms
APOA1(25-266), P15497
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Heme signaling (Bos taurus)
FeHM oxidises LDL,HDL (Bos taurus)
LDL,HDL [extracellular region] (Bos taurus)
discoidal HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
oxidized LDL,HDL [extracellular region] (Bos taurus)
oxidized discoidal HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
oxidized spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
Release of platelet secretory granule components (Bos taurus)
Platelet releasate secretory granule proteins [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Metabolism (Bos taurus)
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of fat-soluble vitamins (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
CR:atREs binds apoE and HSPG (Bos taurus)
CR:atREs [extracellular region] (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
CR:atREs:HSPG:apoE [plasma membrane] (Bos taurus)
CR:atREs [extracellular region] (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Cytosolic CMs translocate to extracellular region (Bos taurus)
nascent CM:atREs [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
LPL hydrolyses TGs from mature CMs (Bos taurus)
CR:atREs [extracellular region] (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
mature CM:atREs [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Bos taurus)
CR:atREs:HSPG:apoE [plasma membrane] (Bos taurus)
CR:atREs [extracellular region] (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Nascent CMs transform into mature CMs (Bos taurus)
mature CM:atREs [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
nascent CM:atREs [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
Retinoid metabolism and transport (Bos taurus)
CR:atREs binds apoE and HSPG (Bos taurus)
CR:atREs [extracellular region] (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
CR:atREs:HSPG:apoE [plasma membrane] (Bos taurus)
CR:atREs [extracellular region] (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Cytosolic CMs translocate to extracellular region (Bos taurus)
nascent CM:atREs [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
LPL hydrolyses TGs from mature CMs (Bos taurus)
CR:atREs [extracellular region] (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
mature CM:atREs [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Bos taurus)
CR:atREs:HSPG:apoE [plasma membrane] (Bos taurus)
CR:atREs [extracellular region] (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Nascent CMs transform into mature CMs (Bos taurus)
mature CM:atREs [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
nascent CM:atREs [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Transport of small molecules (Bos taurus)
Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
Plasma lipoprotein assembly (Bos taurus)
Chylomicron assembly (Bos taurus)
nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron (Bos taurus)
chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
nascent chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Bos taurus)
nascent chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
HDL assembly (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
discoidal HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)
discoidal HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
pre-beta HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Plasma lipoprotein clearance (Bos taurus)
HDL clearance (Bos taurus)
Disassembly of SR-BI-bound spherical HDL (Bos taurus)
pre-beta HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
HDLBP binds HDL (Bos taurus)
HDLBP:HDL [plasma membrane] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
apoA-I binds to CUBN:AMN (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL and SR-BI receptor form a complex at the cell surface (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Plasma lipoprotein remodeling (Bos taurus)
Chylomicron remodeling (Bos taurus)
TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
chylomicron [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
HDL remodeling (Bos taurus)
Discoidal HDL binds membrane-associated free cholesterol (Bos taurus)
discoidal HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
discoidal HDL:cholesterol [extracellular region] (Bos taurus)
discoidal HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Bos taurus)
LCAT:discoidal HDL complex [extracellular region] (Bos taurus)
discoidal HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
discoidal HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
LCAT + spherical HDL <=> LCAT:spherical HDL complex (Bos taurus)
LCAT:spherical HDL complex [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Bos taurus)
LCAT:discoidal HDL complex [extracellular region] (Bos taurus)
discoidal HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
discoidal HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
LCAT:spherical HDL complex <=> LCAT + spherical HDL (Bos taurus)
LCAT:spherical HDL complex [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Spherical HDL binds C and E apolipoproteins (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Spherical HDL binds membrane-associated free cholesterol and phospholipids (Bos taurus)
enlarged spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
Vesicle-mediated transport (Bos taurus)
Binding and Uptake of Ligands by Scavenger Receptors (Bos taurus)
Scavenging by Class B Receptors (Bos taurus)
Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Bos taurus)
Platelet glycoprotein IV:Ligand [plasma membrane] (Bos taurus)
Ligands of CD36 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
SCARB1 (SR-BI, CLA-1) binds ligands (Bos taurus)
Ligands of SCARB1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
SCARB1:Ligand [plasma membrane] (Bos taurus)
Ligands of SCARB1 [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
APOA1 [extracellular region] (Bos taurus)
External Reference Information
External Reference
UniProt:P15497
Gene Names
APOA1
Reference Genes
BioGPS Gene:281631 APOA1
ENSEMBL:ENSBTAG00000002258
ENSEMBL:ENSBTAG00000002258.3 APOA1
KEGG Gene (Bos taurus):281631 APOA1
Monarch:281631 APOA1
NCBI Gene:281631 APOA1
Reference Transcript
RefSeq:NM_174242.3 APOA1
Participates
as a member of
Platelet releasate secretory granule proteins [extracellular region] (Bos taurus)
as a component of
nascent CM:atREs [extracellular region] (Bos taurus)
mature CM:atREs [extracellular region] (Bos taurus)
spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region] (Bos taurus)
TG-depleted chylomicron [extracellular region] (Bos taurus)
enlarged spherical HDL [extracellular region] (Bos taurus)
chylomicron [extracellular region] (Bos taurus)
nascent chylomicron [extracellular region] (Bos taurus)
pre-beta HDL [extracellular region] (Bos taurus)
oxidized spherical HDL [extracellular region] (Bos taurus)
oxidized discoidal HDL [extracellular region] (Bos taurus)
discoidal HDL [extracellular region] (Bos taurus)
spherical HDL [extracellular region] (Bos taurus)
as an input of
apoA-I binds to CUBN:AMN (Bos taurus)
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Bos taurus)
as an output of
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Bos taurus)
This entity regulates
Positively
cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)
(Bos taurus)
Other forms of this molecule
APOA1 [secretory granule lumen]
APOA1 [cytosol]
APOA1 [early endosome]
APOA1 [endoplasmic reticulum lumen]
APOA1 [extracellular region]
APOA1 [plasma membrane]
APOA1 [endocytic vesicle lumen]
phospho-APOA1 [endoplasmic reticulum lumen]
APOA1 [endoplasmic reticulum lumen]
Inferred From
APOA1(25-266) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_776667.2
OpenTargets
ENSG00000118137
VGNC
26022
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