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phospho-SHC1 [cytosol]
Stable Identifier
R-BTA-180276
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
p-Y349,Y350-SHC1, Q0IIE2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Bos taurus)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
SHC1 events in EGFR signaling (Bos taurus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
SHC1 phosphorylation by phosphorylated EGFR (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
Signaling by ERBB2 (Bos taurus)
SHC1 events in ERBB2 signaling (Bos taurus)
SHC1 phosphorylation by ERBB2 heterodimers (Bos taurus)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
Signaling by ERBB4 (Bos taurus)
SHC1 events in ERBB4 signaling (Bos taurus)
Phosphorylation of SHC1 by ERBB4 homodimers (Bos taurus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Bos taurus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
phospho-SHC1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q0IIE2
Gene Names
SHC1
Reference Genes
BioGPS Gene:507196 SHC1
ENSEMBL:ENSBTAG00000019838
KEGG:bta:507196 SHC1
Monarch:507196 SHC1
NCBI Entrez Gene:507196 SHC1
UCSC:Q0IIE2 SHC1
Reference Transcript
RefSeq:NM_001075305.2 SHC1
RefSeq:NM_001164061.1 SHC1
Participates
as a component of
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Bos taurus)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Bos taurus)
Other forms of this molecule
SHC1 [plasma membrane]
SHC1 [plasma membrane]
SHC1 [plasma membrane]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
SHC1 [cytosol]
SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [plasma membrane]
phospho-SHC1 [plasma membrane]
phospho-SHC1 [cytosol]
SHC1 [cytosol]
phospho-SHC1 [cytosol]
Inferred From
p-Y349,Y350-SHC1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 349 (in Homo sapiens)
Coordinate
349
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 350 (in Homo sapiens)
Coordinate
350
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001157533.1
,
NP_001068773.1
VGNC
34590
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