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PIK3CA:PIK3R1 [cytosol]
Stable Identifier
R-BTA-1806218
Type
Complex
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PIK3C(1) [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)
PIK3(2) [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PI3K bound to EPOR [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
GAB1 signalosome (Bos taurus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Bos taurus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Bos taurus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Signaling by MET (Bos taurus)
MET activates PI3K/AKT signaling (Bos taurus)
MET bound PI3K generates PIP3 (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
Phosphorylated GAB1 recruits PI3K to MET (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PIK3CA [cytosol]
(Bos taurus)
PIK3R1 [cytosol]
(Bos taurus)
Participates
as a member of
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3C(1) [cytosol] (Bos taurus)
PIK3(2) [cytosol] (Bos taurus)
as an input of
Phosphorylated GAB1 recruits PI3K to MET (Bos taurus)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Bos taurus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Bos taurus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Bos taurus)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Bos taurus)
as a component of
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
Inferred From
PIK3CA:PIK3R1 [cytosol]
(Homo sapiens)
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