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HGS [cytosol]
Stable Identifier
R-BTA-182954
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
Q0V8S0
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ub-specific processing proteases (Bos taurus)
USP8 deubiquitinates STAM2:HGS (Bos taurus)
USP8:STAM2:HGS [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
USP8:Ub-STAM2:HGS [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
CBL-mediated ubiquitination of CIN85 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
EGFR binds EPS15, EPN1, EPS15L1 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
EGFR non-clathrin mediated endocytosis (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
EGFR phosphorylates EPS15 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PTPN3 dephosphorylates EPS15 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Sprouty sequesters CBL away from active EGFR (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Signaling by MET (Bos taurus)
Negative regulation of MET activity (Bos taurus)
EPS15 and HGS bind ubiquitinated MET (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
RHOBTB3 ATPase cycle (Bos taurus)
RHOBTB3 binds interacting proteins at trans-Golgi network (Bos taurus)
RHOBTB3 interacting proteins [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Bos taurus)
RHOBTB3 interacting proteins [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
RHOU GTPase cycle (Bos taurus)
RHOU binds effectors at the plasma membrane (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
RHOU:GTP:RHOU effectors [plasma membrane] (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
BAR domain proteins recruit dynamin (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Cargo recognition for clathrin-mediated endocytosis (Bos taurus)
Epsin family proteins bind ubiquitinated cargo (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Clathrin recruits PIK3C2A (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
F- and N- BAR domain proteins bind the clathrin-coated pit (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
RAB5 and GAPVD1 bind AP-2 (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
SNX9 recruits components of the actin polymerizing machinery (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Bos taurus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Bos taurus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Bos taurus)
CLASP proteins:cargo [plasma membrane] (Bos taurus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Bos taurus)
ubiquitinated cargo [plasma membrane] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
Endosomal Sorting Complex Required For Transport (ESCRT) (Bos taurus)
Cargo Recognition And Sorting (Bos taurus)
ESCRT-0 [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
ESCRT-0/Cargo Complex [endosome membrane] (Bos taurus)
ESCRT-0 [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
trans-Golgi Network Vesicle Budding (Bos taurus)
Lysosome Vesicle Biogenesis (Bos taurus)
AP1G2 binds HGS and CHMP2A (Bos taurus)
AP1G2:HGS:CHMP2A [Golgi membrane] (Bos taurus)
HGS [cytosol] (Bos taurus)
HGS [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q0V8S0
Reference Genes
BioGPS Gene:511582
ENSEMBL:ENSBTAG00000000411
KEGG Gene (Bos taurus):511582
Monarch:511582
NCBI Gene:511582
Reference Transcript
RefSeq:NM_001046089.1
RefSeq:XM_005221033.3
Other Identifiers
GO:0005737
GO:0005764
GO:0005768
GO:0005769
GO:0005773
GO:0005829
GO:0006622
GO:0006886
GO:0008289
GO:0010324
GO:0010628
GO:0010642
GO:0015031
GO:0016020
GO:0016192
GO:0016525
GO:0019904
GO:0023052
GO:0030948
GO:0031410
GO:0031623
GO:0031901
GO:0032456
GO:0032585
GO:0033565
GO:0035091
GO:0043130
GO:0043226
GO:0044389
GO:0046426
GO:0046872
GO:0048856
GO:0061024
GO:0072657
GO:1903543
Participates
as a component of
ESCRT-0 [cytosol] (Bos taurus)
AP1G2:HGS:CHMP2A [Golgi membrane] (Bos taurus)
USP8:STAM2:HGS [cytosol] (Bos taurus)
USP8:Ub-STAM2:HGS [cytosol] (Bos taurus)
EPS15:HGS:STAM [cytosol] (Bos taurus)
p-Eps15:HGS:STAM [cytosol] (Bos taurus)
as an input of
AP1G2 binds HGS and CHMP2A (Bos taurus)
as a candidate of
RHOU effectors [cytosol] (Bos taurus)
as a member of
RHOBTB3 interacting proteins [cytosol] (Bos taurus)
Inferred From
HGS [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005221090.1
,
NP_001039554.1
Ensembl
ENSBTAT00000000527
,
ENSBTAP00000000527
,
ENSBTAG00000000411
VGNC
29836
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