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PDGFA [extracellular region]
Stable Identifier
R-BTA-184199
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
extracellular region
Synonyms
PDGFA-1, Q2KJ15
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
Exocytosis of platelet alpha granule contents (Bos taurus)
Platelet alpha granule contents [extracellular region] (Bos taurus)
PDGF dimer [extracellular region] (Bos taurus)
PDGF AB heterodimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by PDGF (Bos taurus)
Autophosphorylation of PDGF alpha receptors (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Downstream signal transduction (Bos taurus)
Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Activation of Src (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Crk binds to the active PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
GRB2:SOS1 complex binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Grb7 binds to the active PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Nck binds to the active PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PI3-kinase binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PLC-gamma binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
Phosphorylation of PLCgamma by PDGFR (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
SH2 domain of Src binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
SHP2 binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
STAT binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
p130Cas and C3G bind PDGFR bound Crk (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF binds to extracellular matrix proteins (Bos taurus)
PDGF A and B chains with retention motif [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF A and B chains:ECM complex [extracellular region] (Bos taurus)
PDGF A and B chains with retention motif [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF dimer binds two receptors simultaneously (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF:PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGF-AA clevage by Furin (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGFRs bind type I TKI (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFA [extracellular region] (Bos taurus)
External Reference Information
External Reference
UniProt:Q2KJ15
Gene Names
PDGFA
Reference Genes
BioGPS Gene:505908 PDGFA
ENSEMBL:ENSBTAG00000014541
KEGG Gene (Bos taurus):505908 PDGFA
Monarch:505908 PDGFA
NCBI Gene:505908 PDGFA
Reference Transcript
RefSeq:NM_001075231.1 PDGFA
Other Identifiers
505908
GO:0005161
GO:0005518
GO:0005576
GO:0005615
GO:0006629
GO:0008083
GO:0008284
GO:0009611
GO:0009986
GO:0010512
GO:0010544
GO:0014910
GO:0016020
GO:0023052
GO:0030335
GO:0031954
GO:0035793
GO:0036211
GO:0042060
GO:0042803
GO:0043406
GO:0043410
GO:0048008
GO:0048018
GO:0048146
GO:0048856
GO:0048870
GO:0050919
GO:0051781
GO:0051897
GO:0070374
GO:0098772
Participates
as a component of
PDGF AB heterodimer [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
as a member of
PDGF A and B chains with retention motif [extracellular region] (Bos taurus)
Other forms of this molecule
PDGFA [platelet alpha granule lumen]
PDGFA [endoplasmic reticulum lumen]
PDGFA [endoplasmic reticulum lumen]
PDGFA [Golgi lumen]
PDGFA [Golgi membrane]
PDGFA [Golgi membrane]
PDGFA [extracellular region]
Inferred From
Active platelet-derived growth factor A chain isoforms [extracellular region]
(Homo sapiens)
PDGFA-1 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001068699.1
OpenTargets
ENSG00000197461
Ensembl
ENSBTAG00000014541
,
ENSBTAP00000019323
,
ENSBTAT00000019323
VGNC
32689
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