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phospho-p-S272,T222,T334-MAPKAPK2 [cytosol]
Stable Identifier
R-BTA-187760
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
A0A3Q1M614
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
ALOX5 is phosphorylated by MAPKAP2 (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Metabolism of RNA (Bos taurus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Bos taurus)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Bos taurus)
MK2 phosphorylates BRF1 (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (Bos taurus)
MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
TNF signaling (Bos taurus)
Regulation of TNFR1 signaling (Bos taurus)
MAPKAPK2 phosphorylates RIPK1 at S320 (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
Signalling to ERKs (Bos taurus)
Signalling to RAS (Bos taurus)
p38MAPK events (Bos taurus)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
p-MAPK2/3 phosphorylates HSP27 (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1M614
Reference Genes
ENSEMBL:ENSBTAG00000038107.3
Other Identifiers
788091
GO:0000166
GO:0002224
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004683
GO:0005516
GO:0005524
GO:0005634
GO:0005737
GO:0006468
GO:0006954
GO:0009931
GO:0016740
GO:0023052
GO:0034097
GO:0035556
GO:0035924
GO:0036211
GO:0043226
GO:0048010
GO:0050896
GO:0051019
GO:0098542
GO:0140096
Participates
as a member of
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Bos taurus)
Other forms of this molecule
MAPKAPK2 [cytosol]
phospho-p-T222,S272-MAPKAPK2 [nucleoplasm]
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
MAPKAPK2 [nucleoplasm]
Inferred From
p-S272,T222,T334-MAPKAPK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 272 (in Homo sapiens)
Coordinate
272
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 334 (in Homo sapiens)
Coordinate
334
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
Ensembl
ENSBTAP00000069160
,
ENSBTAG00000038107
,
ENSBTAT00000084476
VGNC
54449
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