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Cyclin E:p-T160-CDK2 [nucleoplasm]
Stable Identifier
R-BTA-188362
Type
Complex
Species
Bos taurus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
Mitotic G1 phase and G1/S transition (Bos taurus)
G1 Phase (Bos taurus)
Cyclin D associated events in G1 (Bos taurus)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
G1/S Transition (Bos taurus)
Cyclin E associated events during G1/S transition (Bos taurus)
Association of Rb with Cyclin E:Cdk2 complexes (Bos taurus)
CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes (Bos taurus)
Cyclin E:CDK2-mediated phosphorylation of RB1 (Bos taurus)
CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Bos taurus)
Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Ubiquitination of phospho-p27/p21 (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
SCF(Skp2)-mediated degradation of p27/p21 (Bos taurus)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Bos taurus)
Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Ubiquitination of phospho-p27/p21 (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Bos taurus)
Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cdc6 protein is phosphorylated by CDK (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
DNA Replication (Bos taurus)
Synthesis of DNA (Bos taurus)
Switching of origins to a post-replicative state (Bos taurus)
CDK-mediated phosphorylation and removal of Cdc6 (Bos taurus)
Cdc6 protein is phosphorylated by CDK (Bos taurus)
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:p-T160-CDK2 [nucleoplasm] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Cyclin E [nucleoplasm]
(Bos taurus)
phospho-p-T160-CDK2 [nucleoplasm]
(Bos taurus)
Participates
as an output of
Cyclin E:CDK2-mediated phosphorylation of RB1 (Bos taurus)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Bos taurus)
as an input of
Association of Rb with Cyclin E:Cdk2 complexes (Bos taurus)
as a component of
CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] (Bos taurus)
as a member of
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Bos taurus)
This entity regulates
Negatively
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes
(Bos taurus)
Inferred From
Cyclin E:p-T160-CDK2 [nucleoplasm]
(Homo sapiens)
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