Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ARHGEF6 [cytosol]
Stable Identifier
R-BTA-195017
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
ARHGEF6, E1BIM5
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Bos taurus)
Cell junction organization (Bos taurus)
Cell-extracellular matrix interactions (Bos taurus)
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Bos taurus)
PARVB/Affixin interacts with alpha PIX (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
ParvB/Affixin:Alpha-Pix [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
Cell death signalling via NRAGE, NRIF and NADE (Bos taurus)
NRAGE signals death through JNK (Bos taurus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Bos taurus)
GEFs [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (12/13) signalling events (Bos taurus)
GEFs activate RhoA,B,C (Bos taurus)
GEFs [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through CDC42 (Bos taurus)
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
PAK1 binds ARHGEF6 (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Bos taurus)
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
CDC42 GTPase cycle (Bos taurus)
CDC42 GEFs activate CDC42 (Bos taurus)
CDC42 GEFs [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
RAC1 GTPase cycle (Bos taurus)
RAC1 GEFs activate RAC1 (Bos taurus)
RAC1 GEFs [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
RHOU GTPase cycle (Bos taurus)
RHOU binds effectors at the plasma membrane (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
RHOU:GTP:RHOU effectors [plasma membrane] (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
ARHGEF6 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:E1BIM5
Gene Names
ARHGEF6
Reference Genes
ENSEMBL:ENSBTAG00000017850.6
ENSEMBL:ENSBTAG00000017850.7 ARHGEF6
Other Identifiers
GO:0005085
GO:0005737
GO:0023052
GO:0030027
GO:0030032
GO:0035556
GO:0098772
Participates
as a candidate of
CDC42 GEFs [cytosol] (Bos taurus)
RAC1 GEFs [cytosol] (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
as an output of
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Bos taurus)
as an input of
PAK1 binds ARHGEF6 (Bos taurus)
PARVB/Affixin interacts with alpha PIX (Bos taurus)
as a component of
Active PAK1:ARHGEF6 [cytosol] (Bos taurus)
ParvB/Affixin:Alpha-Pix [cytosol] (Bos taurus)
as a member of
GEFs [cytosol] (Bos taurus)
Inferred From
ARHGEF6 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000129675
Ensembl
ENSBTAG00000017850
,
ENSBTAP00000023731
,
ENSBTAT00000023731
VGNC
26120
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text