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VAV1 [cytosol]
Stable Identifier
R-BTA-195066
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
VAV1, Q08DN7
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
VAV1 is a GEF for Rho/Rac family GTPases (Bos taurus)
PIP3:VAV1,2,3 [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
VAV family:PIP2 [plasma membrane] (Bos taurus)
VAV family [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
p-SLP-76 binds VAV (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
p-SLP-76:VAV [cytosol] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
CD28 co-stimulation (Bos taurus)
CD28 dependent Vav1 pathway (Bos taurus)
Activation of Vav1 (Bos taurus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Translocation of Vav1 to CD28 (Bos taurus)
VAV1 [cytosol] (Bos taurus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BTK binds BTK inhibitors (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
BTK:BTK inhibitors [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
IL3 stimulation induces Vav binding to Tec kinase (Bos taurus)
TEC:VAV1 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL binds VAV (Bos taurus)
VAV1 [cytosol] (Bos taurus)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Autophosphorylation of BTK/ITK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Phosphorylation of TEC kinases by p-SYK (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
FCERI mediated MAPK activation (Bos taurus)
Phosphorylation and activation of VAV (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Recruitment of VAV to p-SLP-76 (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Phosphorylation of VAV (Bos taurus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Recruitment of VAV1 to p-6Y-SYK (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Death Receptor Signaling (Bos taurus)
p75 NTR receptor-mediated signalling (Bos taurus)
Cell death signalling via NRAGE, NRIF and NADE (Bos taurus)
NRAGE signals death through JNK (Bos taurus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Bos taurus)
GEFs [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates RAS (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Bos taurus)
GRB2-1:VAV1 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
GRB2-1:VAV1 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (12/13) signalling events (Bos taurus)
GEFs activate RhoA,B,C (Bos taurus)
GEFs [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
Phosphorylation and activation of VAV1 (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
Src kinases phosphorylate VAV (Bos taurus)
PIP3:VAV1,2,3 [plasma membrane] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)
VAV family [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
RAC1 GTPase cycle (Bos taurus)
RAC1 GEFs activate RAC1 (Bos taurus)
RAC1 GEFs [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
RAC2 GTPase cycle (Bos taurus)
RAC2 GEFs activate RAC2 (Bos taurus)
RAC2 GEFs [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
RHOA GTPase cycle (Bos taurus)
RHOA GEFs activate RHOA (Bos taurus)
RHOA GEFs [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
RHOG GTPase cycle (Bos taurus)
RHOG GEFs activate RHOG (Bos taurus)
RHOG GEFs [cytosol] (Bos taurus)
VAV1 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:Q08DN7
Gene Names
VAV1
Reference Genes
BioGPS Gene:617345 VAV1
ENSEMBL:ENSBTAG00000039160
ENSEMBL:ENSBTAG00000039160.3 VAV1
KEGG Gene (Bos taurus):617345 VAV1
Monarch:617345 VAV1
NCBI Gene:617345 VAV1
Reference Transcript
RefSeq:NM_001078074.1 VAV1
Other Identifiers
617345
GO:0001784
GO:0002376
GO:0005085
GO:0005515
GO:0005911
GO:0006909
GO:0006955
GO:0007155
GO:0007186
GO:0007229
GO:0008361
GO:0016192
GO:0023052
GO:0030154
GO:0030217
GO:0030593
GO:0035556
GO:0042110
GO:0045785
GO:0045954
GO:0048856
GO:0048870
GO:0072593
GO:0098542
GO:0098772
GO:0140031
Participates
as a component of
GRB2-1:VAV1 [cytosol] (Bos taurus)
TEC:VAV1 [cytosol] (Bos taurus)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Bos taurus)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
as a member of
RHOA GEFs [cytosol] (Bos taurus)
RAC2 GEFs [cytosol] (Bos taurus)
RAC1 GEFs [cytosol] (Bos taurus)
RHOG GEFs [cytosol] (Bos taurus)
GEFs [cytosol] (Bos taurus)
VAV family [cytosol] (Bos taurus)
VAV1,2,3 [cytosol] (Bos taurus)
as an input of
IL3 stimulation induces Vav binding to Tec kinase (Bos taurus)
CBL binds VAV (Bos taurus)
Phosphorylation and activation of VAV1 (Bos taurus)
Translocation of Vav1 to CD28 (Bos taurus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)
Other forms of this molecule
phospho-VAV1 [plasma membrane]
phospho-VAV1 [cytosol]
VAV1 [plasma membrane]
Inferred From
VAV1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001071542.1
OpenTargets
ENSG00000141968
Ensembl
ENSBTAT00000056825
,
ENSBTAP00000050922
,
ENSBTAG00000039160
VGNC
36772
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