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PI3K alpha [cytosol]
Stable Identifier
R-BTA-198379
Type
Complex
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
RET signaling (Bos taurus)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI3K alpha, beta, gamma [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Regulation of T cell activation by CD28 family (Bos taurus)
Co-stimulation by CD28 (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K binds CD28 (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Co-stimulation by ICOS (Bos taurus)
PI3K binds ICOS (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL ubiquitinates PI3K (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
RAC1,RAC2,RHOG activate PI3K (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (q) signalling events (Bos taurus)
G alpha (q) inhibits PI3K alpha (Bos taurus)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
PI3K binds membrane-associated estrogen receptors (Bos taurus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PTK2 is recruited to methylated ESR1 (Bos taurus)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Bos taurus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
Direct recruitment of PI3K to p-KIT (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
RAC1 GTPase cycle (Bos taurus)
RAC1 binds effectors at the plasma membrane (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
RAC2 GTPase cycle (Bos taurus)
RAC2 binds effectors at the plasma membrane (Bos taurus)
RAC2 plasma membrane effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Bos taurus)
RAC2 plasma membrane effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PI3K-regulatory subunits [cytosol]
(Bos taurus)
PIK3CA [cytosol]
(Bos taurus)
Participates
as a member of
RAC2 plasma membrane effectors [cytosol] (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha, beta, gamma [cytosol] (Bos taurus)
as an input of
PI3K binds membrane-associated estrogen receptors (Bos taurus)
G alpha (q) inhibits PI3K alpha (Bos taurus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
RAC1,RAC2,RHOG activate PI3K (Bos taurus)
Direct recruitment of PI3K to p-KIT (Bos taurus)
as a component of
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Bos taurus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Bos taurus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
as a candidate of
Class 1A PI3Ks [cytosol] (Bos taurus)
Inferred From
PI3K alpha [cytosol]
(Homo sapiens)
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