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PTEN [cytosol]
Stable Identifier
R-BTA-199420
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
PTEN, F1MDX9
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
PTEN dephosphorylates PIP3 (Bos taurus)
PTEN [cytosol] (Bos taurus)
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)
PTEN:Mg2+ [cytosol] (Bos taurus)
PTEN [cytosol] (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)
PTEN [cytosol] (Bos taurus)
PTEN dephosphorylates PIP3 (Bos taurus)
PTEN [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ovarian tumor domain proteases (Bos taurus)
OTUD3 deubiquitinates PTEN (Bos taurus)
PTEN [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PTEN dephosphorylates PIP3 (Bos taurus)
PTEN [cytosol] (Bos taurus)
PTEN Regulation (Bos taurus)
Regulation of PTEN localization (Bos taurus)
Deubiquitinated PTEN translocates to the cytosol (Bos taurus)
PTEN [cytosol] (Bos taurus)
PTEN undergoes monoubiquitination (Bos taurus)
PTEN [cytosol] (Bos taurus)
Regulation of PTEN stability and activity (Bos taurus)
Casein kinase II phosphorylates PTEN (Bos taurus)
PTEN [cytosol] (Bos taurus)
FRK phosphorylates PTEN (Bos taurus)
PTEN:p-Y387-FRK [cytosol] (Bos taurus)
PTEN [cytosol] (Bos taurus)
MKRN1 polyubiquitinates PTEN (Bos taurus)
PTEN [cytosol] (Bos taurus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)
PTEN [cytosol] (Bos taurus)
PREX2 binds PTEN and inhibits it (Bos taurus)
PREX2:PTEN,p-3S,2T-PTEN [cytosol] (Bos taurus)
PTEN, p-3S,2T-PTEN [cytosol] (Bos taurus)
PTEN [cytosol] (Bos taurus)
PTEN, p-3S,2T-PTEN [cytosol] (Bos taurus)
PTEN [cytosol] (Bos taurus)
PTEN binds FRK (Bos taurus)
PTEN [cytosol] (Bos taurus)
PTEN:p-Y387-FRK [cytosol] (Bos taurus)
PTEN [cytosol] (Bos taurus)
TNKS and TNKS2 PARylate PTEN (Bos taurus)
PTEN [cytosol] (Bos taurus)
TRIM27 binds PTEN (Bos taurus)
PTEN [cytosol] (Bos taurus)
PTEN:TRIM27 [cytosol] (Bos taurus)
PTEN [cytosol] (Bos taurus)
TRIM27 polyubiquitinates PTEN (Bos taurus)
PTEN:TRIM27 [cytosol] (Bos taurus)
PTEN [cytosol] (Bos taurus)
USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)
PTEN [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MDX9
Gene Names
PTEN
Reference Genes
ENSEMBL:ENSBTAG00000009498.6
UCSC:F1MDX9 PTEN
Other Identifiers
540786
Participates
as an output of
OTUD3 deubiquitinates PTEN (Bos taurus)
USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)
Deubiquitinated PTEN translocates to the cytosol (Bos taurus)
as a member of
PTEN, p-3S,2T-PTEN [cytosol] (Bos taurus)
as an input of
MKRN1 polyubiquitinates PTEN (Bos taurus)
TNKS and TNKS2 PARylate PTEN (Bos taurus)
PTEN binds FRK (Bos taurus)
Casein kinase II phosphorylates PTEN (Bos taurus)
TRIM27 binds PTEN (Bos taurus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)
PTEN undergoes monoubiquitination (Bos taurus)
as a component of
PTEN:p-Y387-FRK [cytosol] (Bos taurus)
PTEN:TRIM27 [cytosol] (Bos taurus)
PTEN:Mg2+ [cytosol] (Bos taurus)
Other forms of this molecule
PTEN [cytosol]
PTEN [nucleoplasm]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
PTEN [cytosol]
PTEN [cytosol]
PTEN [cytosol]
PTEN [cytosol]
PTEN [nucleoplasm]
PTEN [nucleoplasm]
Inferred From
PTEN [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAT00000012499
,
ENSBTAP00000012499
VGNC
33496
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