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GRB2 [plasma membrane]
Stable Identifier
R-BTA-202993
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
plasma membrane
Synonyms
GRB2-1, Q3T0F9
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)
BLNK (SLP-65) Signalosome [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Bos taurus)
GRB2 [plasma membrane] (Bos taurus)
BTK binds BTK inhibitors (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Bos taurus)
GRB2 [plasma membrane] (Bos taurus)
BTK:BTK inhibitors [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Bos taurus)
GRB2 [plasma membrane] (Bos taurus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
GRB2 [plasma membrane] (Bos taurus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Bos taurus)
GRB2 [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Bos taurus)
GRB2 [plasma membrane] (Bos taurus)
p-6Y-SYK phosphorylates BLNK (SLP65) (Bos taurus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Bos taurus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Bos taurus)
GRB2 [plasma membrane] (Bos taurus)
p-CD19:VAV binds PI3K and GRB2 (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
GRB2 [plasma membrane] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
GRB2 [plasma membrane] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
GRB2 [plasma membrane] (Bos taurus)
External Reference Information
External Reference
UniProt:Q3T0F9
Gene Names
GRB2
Reference Genes
BioGPS Gene:535298 GRB2
ENSEMBL:ENSBTAG00000004736.5
KEGG Gene (Bos taurus):535298 GRB2
Monarch:535298 GRB2
NCBI Gene:535298 GRB2
Reference Transcript
RefSeq:NM_001034630.1 GRB2
RefSeq:XM_010816566.1 GRB2
Other Identifiers
535298
GO:0001784
GO:0002376
GO:0005068
GO:0005091
GO:0005154
GO:0005168
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005768
GO:0005794
GO:0005886
GO:0005911
GO:0005938
GO:0007010
GO:0007165
GO:0007173
GO:0008180
GO:0008286
GO:0008543
GO:0012506
GO:0014044
GO:0016020
GO:0016192
GO:0017124
GO:0019901
GO:0019903
GO:0019904
GO:0023052
GO:0030036
GO:0030154
GO:0030674
GO:0030838
GO:0031410
GO:0031623
GO:0035987
GO:0042552
GO:0042770
GO:0042802
GO:0043226
GO:0043408
GO:0043560
GO:0046875
GO:0048009
GO:0048646
GO:0048856
GO:0050853
GO:0060090
GO:0060670
GO:0065003
GO:0070436
GO:0071479
GO:0098772
GO:2000379
Participates
as a component of
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Bos taurus)
CD19 Signalosome [plasma membrane] (Bos taurus)
Other forms of this molecule
GRB2 [cytosol]
Inferred From
GRB2-1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_010814868.1
,
NP_001029802.1
OpenTargets
ENSG00000177885
Ensembl
ENSBTAG00000004736
,
ENSBTAP00000006216
,
ENSBTAT00000006216
VGNC
29631
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