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Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
Stable Identifier
R-BTA-203494
Type
Complex
Species
Bos taurus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Costimulation by the CD28 family (Bos taurus)
PD-1 signaling (Bos taurus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
TCR signaling (Bos taurus)
Generation of second messenger molecules (Bos taurus)
Phosphorylation of PLC-gamma1 (Bos taurus)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Bos taurus)
Activated ZAP-70 [plasma membrane] (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
Phosphorylation of SLP-76 (Bos taurus)
Activated ZAP-70 [plasma membrane] (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
Phosphorylation of TBSMs in LAT (Bos taurus)
Activated ZAP-70 [plasma membrane] (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
Translocation of ZAP-70 to Immunological synapse (Bos taurus)
Activation of ZAP-70 (Bos taurus)
Activated ZAP-70 [plasma membrane] (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
PTPN22 dephosphorylates ZAP70 (Bos taurus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
Phosphorylation of ZAP-70 by Lck (Bos taurus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CD4 [plasma membrane]
(Bos taurus)
MHC Class II bearing antigen peptide [plasma membrane]
(Bos taurus)
phospho-LCK [cytosol]
(Bos taurus)
T-cell receptor complex with phosphorylated ITAMs [plasma membrane]
(Bos taurus)
Participates
as an input of
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)
as an output of
Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)
as a component of
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
Activated ZAP-70 [plasma membrane] (Bos taurus)
Inferred From
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
(Homo sapiens)
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