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NCK2 [cytosol]
Stable Identifier
R-BTA-204885
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
NCK2, A6H720
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Bos taurus)
Nephrin family interactions (Bos taurus)
Nephrin binds NCK (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
Nephrin mediated activation of N-WASP (Bos taurus)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Bos taurus)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
Ephrin signaling (Bos taurus)
EFNB:GRB4 binds GIT1 (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
GIT1 binds bPIX (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
PAK binds RAC and bPIX (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
PAKs autophosphorylate (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
PAKs phosphorylate MLC (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
bPIX exchanges GTP for GDP on RAC, activating it (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
p-EFNB binds GRB4 (Bos taurus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
Nck binds to the active PDGF receptor (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
CDC42:GTP binds PAK2 (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
FYN autophosphorylates (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
FYN phosphorylates PAK2 (Bos taurus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
PAK2 autophorylates (Bos taurus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
PAK2 binds NCK (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
p-6Y-VEGFR2 binds FYN (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
p-6Y-VEGFR2 binds NCK (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
p-Y420-FYN is phosphorylated on S21 (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
p38 MAPK activation by VEGFR (Bos taurus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
RHOU GTPase cycle (Bos taurus)
RHOU binds effectors at the plasma membrane (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
RHOU:GTP:RHOU effectors [plasma membrane] (Bos taurus)
RHOU effectors [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
RHOV GTPase cycle (Bos taurus)
RHOV binds effectors at the plasma membrane (Bos taurus)
RHOV effectors [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
RHOV:GTP:RHOV effectors [plasma membrane] (Bos taurus)
RHOV effectors [cytosol] (Bos taurus)
NCK2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A6H720
Gene Names
NCK2
Reference Genes
BioGPS Gene:526430 NCK2
ENSEMBL:ENSBTAG00000015205.6
KEGG:bta:526430 NCK2
Monarch:526430 NCK2
NCBI Gene:526430 NCK2
UCSC:A6H720 NCK2
Reference Transcript
RefSeq:NM_001099036.1 NCK2
RefSeq:XM_005212779.3 NCK2
Other Identifiers
526430
Bt.10999.1.A1_at
Bt.10999.2.S1_at
GO:0005515
GO:0005737
GO:0005783
GO:0005829
GO:0006417
GO:0016477
GO:0030838
GO:0030971
GO:0035591
GO:0036493
GO:0043226
GO:0048013
GO:0048870
GO:0060090
GO:1902237
GO:1903898
Participates
as a candidate of
RHOV effectors [cytosol] (Bos taurus)
as a member of
RHOU effectors [cytosol] (Bos taurus)
NCK1,NCK2 [cytosol] (Bos taurus)
as an input of
p-EFNB binds GRB4 (Bos taurus)
as a component of
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Bos taurus)
Inferred From
NCK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001092506.1
,
XP_005212836.1
ENSEMBL
ENSBTAT00000100797
,
ENSBTAG00000015205
,
ENSBTAP00000095881
VGNC
31914
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