Reactome | SOCS1 [cytosol]

SOCS1 [cytosol]

Stable Identifier

R-BTA-204910

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

SOCS1, F1MSN0

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
      - Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
      - Polyubiquitination of substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
      - Release of E3 from polyubiquitinated substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
      - Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
- Cytokine Signaling in Immune system (Bos taurus)
  - Interferon Signaling (Bos taurus)
    - Interferon alpha/beta signaling (Bos taurus)
      - Activation of JAK kinases (Bos taurus)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
    - Interferon gamma signaling (Bos taurus)
      - Regulation of IFNG signaling (Bos taurus)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
      - Transphosphorylation of JAK1 (Bos taurus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
  - Signaling by CSF3 (G-CSF) (Bos taurus)
    - Inactivation of CSF3 (G-CSF) signaling (Bos taurus)
      - SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Bos taurus)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Bos taurus)
        
        SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-4 and Interleukin-13 signaling (Bos taurus)
      - SOCS5,(SOCS1) bind IL4RA (Bos taurus)
        
        IL4:IL4R:JAK2:IL13RA:TYK2:SOCS5,(SOCS1) [plasma membrane] (Bos taurus)
        
        SOCS5,(SOCS1) [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)
        
        SOCS5,(SOCS1) [cytosol] (Bos taurus)
        
        SOCS1 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MSN0

Gene Names

SOCS1

Reference Genes

BioGPS Gene:518795 SOCS1

ENSEMBL:ENSBTAG00000004386.5

ENSEMBL:ENSBTAG00000004386.6 SOCS1

KEGG Gene (Bos taurus):518795 SOCS1

Monarch:518795 SOCS1

NCBI Gene:518795 SOCS1

Reference Transcript

Other Identifiers

518795

Participates

as a candidate of

SOCS5,(SOCS1) [cytosol] (Bos taurus)

as a member of

SOCS-1 and SOCS-3 [cytosol] (Bos taurus)

Inferred From

SOCS1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_002698010.1, XP_869409.1

OpenTargets

ENSG00000185338

Ensembl

ENSBTAP00000005753, ENSBTAT00000005753, ENSBTAG00000004386

VGNC

35119