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HDAC1 [nucleoplasm]
Stable Identifier
R-BTA-205021
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
HDAC1, Q32PJ8
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
Mitotic G1 phase and G1/S transition (Bos taurus)
G0 and Early G1 (Bos taurus)
Recruitment of HDAC1 by p107 (RBL1) (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Recruitment of HDAC1 by p130 (RBL2) (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Chromatin organization (Bos taurus)
Chromatin modifying enzymes (Bos taurus)
HDACs deacetylate histones (Bos taurus)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Bos taurus)
HDAC1:2-containing complex [nucleoplasm] (Bos taurus)
BHC complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
CoREST complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
NuRD complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Sin3A complex [nucleoplasm] (Bos taurus)
Sin3a core complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Bos taurus)
HDAC1:2-containing complex [nucleoplasm] (Bos taurus)
BHC complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
CoREST complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
NuRD complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Sin3A complex [nucleoplasm] (Bos taurus)
Sin3a core complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
HDAC1:2-containing complex deacetylate histones (Bos taurus)
HDAC1:2-containing complex [nucleoplasm] (Bos taurus)
BHC complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
CoREST complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
NuRD complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Sin3A complex [nucleoplasm] (Bos taurus)
Sin3a core complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Bos taurus)
HDAC1:2-containing complex [nucleoplasm] (Bos taurus)
BHC complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
CoREST complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
NuRD complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Sin3A complex [nucleoplasm] (Bos taurus)
Sin3a core complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Developmental Biology (Bos taurus)
MITF-M-regulated melanocyte development (Bos taurus)
MITF-M-dependent gene expression (Bos taurus)
Regulation of MITF-M-dependent genes involved in apoptosis (Bos taurus)
HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation (Bos taurus)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase I Transcription (Bos taurus)
RNA Polymerase I Promoter Clearance (Bos taurus)
RNA Polymerase I Transcription Initiation (Bos taurus)
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Bos taurus)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Bos taurus)
NuRD complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Notch-HLH transcription pathway (Bos taurus)
Formation of CSL NCOR corepressor complex (Bos taurus)
HDAC [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
RBPJ:NCOR corepressor complex [nucleoplasm] (Bos taurus)
HDAC [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Transcriptional Regulation by MECP2 (Bos taurus)
Regulation of MECP2 expression and activity (Bos taurus)
MECP2 binds the SIN3A co-repressor complex (Bos taurus)
MECP2:SIN3A:HDAC1,HDAC2 [nucleoplasm] (Bos taurus)
MECP2:SIN3A:HDAC1 [nucleoplasm] (Bos taurus)
SIN3A:HDAC1 homodimer [nucleoplasm] (Bos taurus)
HDAC1 homodimer [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Bos taurus)
SIN3A:HDAC1 homodimer [nucleoplasm] (Bos taurus)
HDAC1 homodimer [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
Regulation of TP53 Activity (Bos taurus)
Regulation of TP53 Activity through Acetylation (Bos taurus)
MTA2-NuRD complex deacetylates TP53 (Bos taurus)
MTA2-NuRD complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Transcriptional regulation by RUNX1 (Bos taurus)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Bos taurus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Bos taurus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Bos taurus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Bos taurus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
RUNX1 binds SIN3A,(SIN3B) co-repressor (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Hemostasis (Bos taurus)
Factors involved in megakaryocyte development and platelet production (Bos taurus)
REST recruits the BHC complex (Bos taurus)
BHC complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
BHC complex:REST:REST DNA binding sites [nucleoplasm] (Bos taurus)
BHC complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
SUMOylation (Bos taurus)
SUMO E3 ligases SUMOylate target proteins (Bos taurus)
SUMOylation of chromatin organization proteins (Bos taurus)
SUMOylation of HDAC1 with SUMO1 (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
PTEN Regulation (Bos taurus)
Regulation of PTEN gene transcription (Bos taurus)
SALL4 recruits NuRD to PTEN gene (Bos taurus)
NuRD complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
SALL4:NuRD:PTEN gene [nucleoplasm] (Bos taurus)
SALL4:NuRD [nucleoplasm] (Bos taurus)
NuRD complex [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Estrogen-dependent gene expression (Bos taurus)
FOXA1 and GATA3 bind to CCND1 promoter (Bos taurus)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
STAT3 nuclear events downstream of ALK signaling (Bos taurus)
HDACs deacetylate p-STAT3 dimers (Bos taurus)
Histone deacetylase [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Signaling by WNT (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Deactivation of the beta-catenin transactivating complex (Bos taurus)
beta-catenin is replaced by repression complexes at the promoter (Bos taurus)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Bos taurus)
TLE:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
TLE1:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
Formation of the beta-catenin:TCF transactivating complex (Bos taurus)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Bos taurus)
TLE:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:Q32PJ8
Gene Names
HDAC1
Reference Genes
BioGPS Gene:404126 HDAC1
ENSEMBL:ENSBTAG00000012698
ENSEMBL:ENSBTAG00000012698.7 HDAC1
KEGG Gene (Bos taurus):404126 HDAC1
Monarch:404126 HDAC1
NCBI Gene:404126 HDAC1
Reference Transcript
RefSeq:NM_001037444.2 HDAC1
Other Identifiers
404126
GO:0000118
GO:0000122
GO:0000228
GO:0000785
GO:0000792
GO:0000976
GO:0000978
GO:0000979
GO:0001046
GO:0001222
GO:0002039
GO:0003677
GO:0003682
GO:0003714
GO:0003824
GO:0004407
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005829
GO:0006325
GO:0006338
GO:0006346
GO:0006351
GO:0006355
GO:0006357
GO:0007492
GO:0007623
GO:0008284
GO:0009913
GO:0010629
GO:0012501
GO:0016581
GO:0016787
GO:0017053
GO:0019899
GO:0021766
GO:0023052
GO:0030154
GO:0030182
GO:0032922
GO:0032991
GO:0033558
GO:0035851
GO:0036211
GO:0042475
GO:0042733
GO:0042826
GO:0043025
GO:0043066
GO:0043124
GO:0043226
GO:0043922
GO:0045892
GO:0045893
GO:0045944
GO:0048709
GO:0048714
GO:0048856
GO:0051059
GO:0060766
GO:0060789
GO:0061029
GO:0061198
GO:0061629
GO:0070822
GO:0070888
GO:0090090
GO:0140096
GO:0140110
GO:0140297
GO:0160009
GO:1990841
GO:2001243
Participates
as an input of
SUMOylation of HDAC1 with SUMO1 (Bos taurus)
HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter (Bos taurus)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Bos taurus)
RUNX1 binds SIN3A,(SIN3B) co-repressor (Bos taurus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Bos taurus)
Recruitment of HDAC1 by p107 (RBL1) (Bos taurus)
Recruitment of HDAC1 by p130 (RBL2) (Bos taurus)
as a component of
HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm] (Bos taurus)
HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] (Bos taurus)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1 homodimer [nucleoplasm] (Bos taurus)
TLE1:HDAC1 [nucleoplasm] (Bos taurus)
TLE:HDAC1 [nucleoplasm] (Bos taurus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm] (Bos taurus)
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] (Bos taurus)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Bos taurus)
HDAC1:HDAC2 [nucleoplasm] (Bos taurus)
as a member of
Histone deacetylase [nucleoplasm] (Bos taurus)
HDAC [nucleoplasm] (Bos taurus)
as an output of
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Bos taurus)
FOXA1 and GATA3 bind to CCND1 promoter (Bos taurus)
Other forms of this molecule
HDAC1 [nucleoplasm]
Inferred From
HDAC1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001032521.1
OpenTargets
ENSG00000116478
Ensembl
ENSBTAP00000016877
,
ENSBTAG00000012698
,
ENSBTAT00000016877
VGNC
49065
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