Reactome | SMC1A [chromosome, centromeric region]

SMC1A [chromosome, centromeric region]

Stable Identifier

R-BTA-2466015

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

chromosome, centromeric region

Synonyms

O97593

Locations in the PathwayBrowser

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Cell Cycle (Bos taurus)

- Cell Cycle, Mitotic (Bos taurus)
  - M Phase (Bos taurus)
    - Mitotic Metaphase and Anaphase (Bos taurus)
      - Mitotic Anaphase (Bos taurus)
        
        Separation of Sister Chromatids (Bos taurus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Bos taurus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Cleaved Cohesin [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        p-RAD21-Ac-Cohesin [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
        
        Separation of sister chromatids (Bos taurus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Cleaved Cohesin [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
    - Mitotic Prometaphase (Bos taurus)
      - Resolution of Sister Chromatid Cohesion (Bos taurus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
        
        Kinetochore assembly (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Bos taurus)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        p-RAD21-Ac-Cohesin [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        p-STAG2,RAD21-Ac-Cohesin [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Bos taurus)
        
        p-STAG2,RAD21-Ac-Cohesin [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)
  - S Phase (Bos taurus)
    - Establishment of Sister Chromatid Cohesion (Bos taurus)
      - CDCA5 (Sororin) enables cohesion of sister centromeres (Bos taurus)
        
        Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Bos taurus)
        
        Centromere:Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL [chromosome, centromeric region] (Bos taurus)
        
        Ac-Cohesin Complex [chromosome, centromeric region] (Bos taurus)
        
        SMC1A [chromosome, centromeric region] (Bos taurus)

External Reference Information

External Reference

UniProt:O97593

Reference Genes

BioGPS Gene:282370

ENSEMBL:ENSBTAG00000017761

KEGG:bta:282370

Monarch:282370

NCBI Gene:282370

UCSC:O97593

Reference Transcript

RefSeq:NM_174614.1

Other Identifiers

282370

GO:0000776

GO:0003682

GO:0003824

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0007010

GO:0007062

GO:0008278

GO:0009314

GO:0016020

GO:0016363

GO:0016787

GO:0016887

GO:0022414

GO:0030892

GO:0030893

GO:0035019

GO:0036033

GO:0043226

GO:0046982

GO:0051321

GO:0072423

GO:0090307

GO:0097431

Participates

as a component of

Other forms of this molecule

SMC1A [cytosol]

SMC1A [chromosome]

SMC1A [nucleoplasm]

Inferred From

SMC1A [chromosome, centromeric region] (Homo sapiens)

Cross References

RefSeq

NP_777039.1

ENSEMBL

ENSBTAG00000017761, ENSBTAP00000090290, ENSBTAT00000113776

VGNC

34997

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