Nckx1 exchanges Na+ for Ca2+/K+

Stable Identifier
R-BTA-2534148
Type
Reaction [transition]
Species
Bos taurus
Compartment
Synonyms
Slc24a1 exchanges Na+ for Ca2+/K+
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Nckx1 exchanges Na+ for Ca2+/K+
The sodium/potassium/calcium exchanger 1 (NCKX1, encoded by SLC24A1), located on the rod outer segment plasma membrane (Reid et al. 1990), is a homodimer (Schwarzer et al. 1997) that is physically linked to the CNG channel (Schwarzer et al. 2000). It mediates the efflux of a Ca2+ ion and a K+ ion in exchange for the influx of 4 Na+ ions, resulting in an overall entry of 1 positive charge (Schnetkamp et al. 1989, Cervetto et al. 1989). When the CNG channels are closed in response to light, the exchanger decreases intracellular Ca2+ by an order of magnitude.
Literature References
PubMed ID Title Journal Year
10788457 Binding of the cGMP-gated channel to the Na/Ca-K exchanger in rod photoreceptors

Schauf, H, Bauer, PJ, Schwarzer, A

J. Biol. Chem. 2000
9354636 The Na/Ca-K exchanger of rod photoreceptor exists as dimer in the plasma membrane.

Hagen, V, Bauer, PJ, Kim, TS, Molday, RS, Schwarzer, A

Biochemistry 1997
2502022 Na+-Ca2+ exchange in bovine rod outer segments requires and transports K+.

Szerencsei, RT, Basu, DK, Schnetkamp, PP

Am J Physiol 1989
2334719 Identification of the sodium-calcium exchanger as the major ricin-binding glycoprotein of bovine rod outer segments and its localization to the plasma membrane

Cook, NJ, Friedel, U, Molday, RS, Reid, DM

Biochemistry 1990
2537471 Extrusion of calcium from rod outer segments is driven by both sodium and potassium gradients.

McNaughton, PA, Perry, RJ, Cervetto, L, Robinson, DW, Lagnado, L

Nature 1989
Participants
Catalyst Activity

calcium, potassium:sodium antiporter activity of Slc24a1 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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