Reactome | Sag binds p-MII to form p-MII:Sag

Sag binds p-MII to form p-MII:Sag

Stable Identifier

R-BTA-2581495

Type

Reaction [binding]

Species

Bos taurus

Compartment

cytosol, photoreceptor disc membrane

ReviewStatus

5/5

General

SBML | | PDF

SVG | | PPTX | SBGN

Although phosphorylation of activated rhodopsin (MII) reduces its activity towards transducin, complete deactivation only occurs after S-arrestin (SAG) binds to and caps MII. The human event is based on experiments performed in cattle (and in mice) (Kuhn & Wilden 1987, Wilden et al. 1986).

Literature References

PubMed ID	Title	Journal	Year
3006038	Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments Kühn, H, Hall, SW, Wilden, U	Proc. Natl. Acad. Sci. U.S.A.	1986
3040978	Deactivation of photoactivated rhodopsin by rhodopsin-kinase and arrestin Kühn, H, Wilden, U	J. Recept. Res.	1987

Participants

Input

Output

p-Rho:Sag [photoreceptor disc membrane] (Bos taurus)

Orthologous Events

SAG binds p-MII to form p-MII:SAG (Homo sapiens)

Authored

Jassal, B (2012-11-13)

Reviewed

Makino, C (2013-04-11)

Created

Jassal, B (2012-11-13)

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