Reactome | HSPA8 [cytosol]

HSPA8 [cytosol]

Stable Identifier

R-BTA-264476

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

P19120

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Interferon Signaling (Bos taurus)
    - Antiviral mechanism by IFN-stimulated genes (Bos taurus)
      - PKR-mediated signaling (Bos taurus)
        
        FA core complex:HSP70s binds PKR (Bos taurus)
        
        FA Core Complex:HSP70s [cytosol] (Bos taurus)
        
        HSP70 proteins [cytosol] (Bos taurus)
        
        HSPA8 [cytosol] (Bos taurus)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Bos taurus)
        
        FA Core Complex:HSP70s [cytosol] (Bos taurus)
        
        HSP70 proteins [cytosol] (Bos taurus)
        
        HSPA8 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:P19120

Reference Genes

BioGPS Gene:281831

ENSEMBL:ENSBTAG00000013162

KEGG:bta:281831

Monarch:281831

NCBI Gene:281831

UCSC:P19120

Reference Transcript

RefSeq:NM_174345.4

Participates

as a component of

as an input of

AUF1 binds translation and heat shock proteins (Bos taurus)

as a member of

HSP70 proteins [cytosol] (Bos taurus)

Other forms of this molecule

HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

HSPA8 [plasma membrane]

HSPA8 [nucleoplasm]

HSPA8 [ficolin-1-rich granule lumen]

HSPA8 [extracellular region]

HSPA8 [secretory granule lumen]

Me3K561-HSPA8 [nucleoplasm]

Inferred From

HSPA8 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_776770.2

ZINC - Metabolites

HSP7C_BOVIN

ZINC - Substances

HSP7C_BOVIN

ZINC - Biogenic

HSP7C_BOVIN

ZINC target

P19120

PRO

P19120

VGNC

54632

ZINC - Predictions - Purchasable

HSP7C_BOVIN

PDB

2QWM, 2QWO, 2QWN, 2QWL, 7PLK, 6H54, 7ODD, 3C7N, 2BUP, 1YUW, 3HSC, 7ODB, 1ATS, 1ATR, 1HX1, 1BA0, 1BA1, 1KAX, 1KAZ, 1KAY, 1HPM, 1NGJ, 2QW9, 1NGB, 1NGD, 1QQM, 1NGE, 1NGC, 1NGF, 1QQN, 1QQO, 1NGG, 1NGI, 1NGH, 1BUP, 1NGA, 7ODI, 2QWP, 2QWQ, 4FL9, 2QWR, 7O6R

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26361	8	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-MMU-8869104) PolyUb-CFTR [plasma membrane] (R-MMU-8867595) CFTR [lysosomal membrane] (R-MMU-5627279) CFTR [Golgi-associated vesicle membrane] (R-MMU-5627079) CFTR [endosome membrane] (R-MMU-6782965) PolyUb-CFTR [endosome membrane] (R-MMU-6782976) CFTR [plasma membrane] (R-MMU-383188) misfolded CFTR [endoplasmic reticulum membrane] (R-MMU-8868730)	0.558	5