Reactome | PIAS4 [nucleoplasm]

PIAS4 [nucleoplasm]

Stable Identifier

R-BTA-2993789

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

PIAS4, A4FV15

Locations in the PathwayBrowser

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DNA Repair (Bos taurus)

- DNA Double-Strand Break Repair (Bos taurus)
  - DNA Double Strand Break Response (Bos taurus)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Bos taurus)
      - ATM phosphorylates HERC2 (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Bos taurus)
        
        PIAS4 [nucleoplasm] (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Bos taurus)
        
        PIAS4 [nucleoplasm] (Bos taurus)
      - HERC2 and PIAS4 are recruited to DNA DSBs (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Bos taurus)
        
        PIAS4 [nucleoplasm] (Bos taurus)
        
        PIAS4 [nucleoplasm] (Bos taurus)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Bos taurus)
        
        PIAS4 [nucleoplasm] (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Bos taurus)
        
        PIAS4 [nucleoplasm] (Bos taurus)
      - RNF8 and RNF168 ubiquitinate H2AFX (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Bos taurus)
        
        PIAS4 [nucleoplasm] (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Bos taurus)
        
        PIAS4 [nucleoplasm] (Bos taurus)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Bos taurus)
        
        PIAS4 [nucleoplasm] (Bos taurus)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Bos taurus)
        
        PIAS4 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:A4FV15

Gene Names

PIAS4

Reference Genes

BioGPS Gene:534722 PIAS4

ENSEMBL:ENSBTAG00000000753

KEGG Gene (Bos taurus):534722 PIAS4

Monarch:534722 PIAS4

NCBI Gene:534722 PIAS4

Reference Transcript

RefSeq:NM_001083482.2 PIAS4

Other Identifiers

534722

Bt.9403.1.S1_at

GO:0000122

GO:0001085

GO:0003674

GO:0003677

GO:0003712

GO:0003714

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0006357

GO:0006464

GO:0006950

GO:0007165

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0009058

GO:0010804

GO:0016363

GO:0016740

GO:0016925

GO:0019789

GO:0019899

GO:0031625

GO:0032088

GO:0032991

GO:0033235

GO:0034641

GO:0043167

GO:0043226

GO:0045892

GO:0046872

GO:0061665

GO:1902174

GO:1902231

GO:1990234

Participates

as an input of

HERC2 and PIAS4 are recruited to DNA DSBs (Bos taurus)

as a component of

Inferred From

PIAS4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001076951.1

OpenTargets

ENSG00000105229

Ensembl

ENSBTAG00000000753, ENSBTAT00000001000, ENSBTAP00000001000

VGNC

32858