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GSK3B [cytosol]
Stable Identifier
R-BTA-2997551
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
GSK3B, F1MIC3
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
Constitutive phosphorylation by GSK3 (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
Semaphorin interactions (Bos taurus)
CRMPs in Sema3A signaling (Bos taurus)
Phosphorylation of CRMPs by GSK3beta (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Hedgehog (Bos taurus)
Hedgehog 'off' state (Bos taurus)
GLI3 is processed to GLI3R by the proteasome (Bos taurus)
GSK3 phosphorylates p-GLI3 (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Signaling by WNT (Bos taurus)
Degradation of beta-catenin by the destruction complex (Bos taurus)
AXIN is phosphorylated in the destruction complex (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Assembly of the destruction complex (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Association of beta-catenin with the destruction complex (Bos taurus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Beta-catenin phosphorylation cascade (Bos taurus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Bos taurus)
FRAT1,2:GSK3beta [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Bos taurus)
FRAT1,2:GSK3beta [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Bos taurus)
FRAT1,2:GSK3beta [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Bos taurus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Phosphorylation of APC component of the destruction complex (Bos taurus)
CK1alpha (GSK3) [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Bos taurus)
Beta-catenin is released from the destruction complex (Bos taurus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
GSK3B:AXIN1 [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Bos taurus)
GSK3B:AXIN1 [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Bos taurus)
GSK3B:AXIN1 [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Bos taurus)
GSK3B:AXIN1 [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
FRAT proteins bind GSK3beta (Bos taurus)
FRAT1,2:GSK3beta [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Bos taurus)
GSK3B [cytosol] (Bos taurus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Bos taurus)
GSK3B:AXIN1 [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Bos taurus)
GSK3B:AXIN1 [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Bos taurus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [early endosome membrane] (Bos taurus)
GSK3B:AXIN1 [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Bos taurus)
GSK3B:AXIN1 [cytosol] (Bos taurus)
GSK3B [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MIC3
Gene Names
GSK3B
Reference Genes
ENSEMBL:ENSBTAG00000048057.2
UCSC:F1MIC3 GSK3B
Other Identifiers
790875
Bt.18755.1.A1_at
Bt.18755.2.S1_at
GO:0001837
GO:0001954
GO:0002020
GO:0002039
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005886
GO:0005975
GO:0005977
GO:0006091
GO:0006468
GO:0006983
GO:0007005
GO:0007399
GO:0008013
GO:0008092
GO:0008286
GO:0009968
GO:0010508
GO:0010628
GO:0010629
GO:0010719
GO:0010975
GO:0016055
GO:0016301
GO:0016740
GO:0019901
GO:0021766
GO:0030154
GO:0030336
GO:0030424
GO:0030877
GO:0031175
GO:0031333
GO:0031334
GO:0031398
GO:0031625
GO:0032007
GO:0032436
GO:0032886
GO:0034236
GO:0034452
GO:0034976
GO:0035556
GO:0043066
GO:0043226
GO:0043525
GO:0045597
GO:0045668
GO:0046825
GO:0046827
GO:0048511
GO:0048856
GO:0050321
GO:0051059
GO:0051093
GO:0060070
GO:0061629
GO:0070507
GO:0070885
GO:0071109
GO:0071300
GO:0090090
GO:0097110
GO:0098793
GO:0098978
GO:0099171
GO:0106310
GO:0140096
GO:0150101
GO:1902042
GO:1903940
GO:1904781
GO:2000740
Participates
as a component of
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
FRAT1,2:GSK3beta [cytosol] (Bos taurus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)
GSK3B:AXIN1 [cytosol] (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
as an input of
Assembly of the destruction complex (Bos taurus)
FRAT proteins bind GSK3beta (Bos taurus)
as a candidate of
CK1alpha (GSK3) [cytosol] (Bos taurus)
Other forms of this molecule
GSK3B [nucleoplasm]
Inferred From
GSK3B [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSBTAT00000056446
,
ENSBTAP00000051604
,
ENSBTAG00000048057
VGNC
106762
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