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LEF1 [nucleoplasm]
Stable Identifier
R-BTA-3214972
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
LEF1, A0A3Q1MZ99
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional regulation by RUNX3 (Bos taurus)
RUNX3 regulates WNT signaling (Bos taurus)
RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Bos taurus)
CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Bos taurus)
TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Bos taurus)
CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Bos taurus)
TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
NLK phosphorylates TCF/LEF (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF7L2,LEF1 [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
Degradation of beta-catenin by the destruction complex (Bos taurus)
Repression of WNT target genes (Bos taurus)
TLE tetramers bind TCF/LEF at WNT promoters (Bos taurus)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Bos taurus)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Deactivation of the beta-catenin transactivating complex (Bos taurus)
TCF:Beta-catenin binds SOX proteins (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:SOX4,SOX13,SOX17 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
beta-catenin is replaced by repression complexes at the promoter (Bos taurus)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
Formation of the beta-catenin:TCF transactivating complex (Bos taurus)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
Beta-catenin recruits CBP/p300 (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
Beta-catenin recruits CDC73 and LEO1 (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
Beta-catenin recruits SMARCA4 (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:SMARCA4:TERT [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
Beta-catenin recruits TRRAP/KAT5 HAT components (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
Beta-catenin:TCF associates with BCL9 and PYGO (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
Recruitment of SET1 methyltransferase complex (Bos taurus)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
SET1 complex trimethylates H3K4 at the MYC gene (Bos taurus)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
LEF1 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1MZ99
Gene Names
LEF1
Reference Genes
BioGPS Gene:535399 LEF1
ENSEMBL:ENSBTAG00000006844.6
Monarch:535399 LEF1
NCBI Gene:535399 LEF1
Reference Transcript
RefSeq:XM_005207653.3 LEF1
Other Identifiers
535399
GO:0000122
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001222
GO:0001227
GO:0001228
GO:0001569
GO:0001649
GO:0001756
GO:0001837
GO:0001944
GO:0002040
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0005634
GO:0005667
GO:0005737
GO:0006310
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0007155
GO:0008013
GO:0008301
GO:0010628
GO:0010718
GO:0012501
GO:0016055
GO:0021542
GO:0021766
GO:0021861
GO:0021873
GO:0021943
GO:0022407
GO:0023052
GO:0030111
GO:0030154
GO:0030177
GO:0030223
GO:0030326
GO:0030331
GO:0030335
GO:0030509
GO:0030854
GO:0030879
GO:0032696
GO:0032713
GO:0032714
GO:0032993
GO:0033153
GO:0042100
GO:0042393
GO:0042475
GO:0042826
GO:0043066
GO:0043226
GO:0043565
GO:0043586
GO:0043923
GO:0045063
GO:0045295
GO:0045588
GO:0045843
GO:0045892
GO:0045893
GO:0045944
GO:0046632
GO:0048341
GO:0048468
GO:0048856
GO:0048870
GO:0050877
GO:0050909
GO:0060033
GO:0060070
GO:0060325
GO:0060326
GO:0060561
GO:0060710
GO:0061153
GO:0062009
GO:0070016
GO:0070742
GO:0071168
GO:0071345
GO:0071353
GO:0071864
GO:0071866
GO:0090575
GO:0098772
GO:0140110
GO:0140416
GO:1901331
GO:1902262
GO:1902732
GO:1904019
GO:1990837
GO:1990907
Participates
as a member of
TCF/LEF [nucleoplasm] (Bos taurus)
TCF/LEF [nucleoplasm] (Bos taurus)
TCF7L2,LEF1 [nucleoplasm] (Bos taurus)
as a candidate of
TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Bos taurus)
TCF7L1/TCF7L2/LEF1 [nucleoplasm] (Bos taurus)
Other forms of this molecule
phospho-LEF1 [nucleoplasm]
Inferred From
LEF1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_005207710.1
OpenTargets
ENSG00000138795
Ensembl
ENSBTAT00000068676
,
ENSBTAP00000061494
,
ENSBTAG00000006844
VGNC
30833
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