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CTNNB1 [nucleoplasm]
Stable Identifier
R-BTA-3451168
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
CTNNB1, Q0VCX4
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional regulation by RUNX3 (Bos taurus)
RUNX3 regulates WNT signaling (Bos taurus)
RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Bos taurus)
CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Bos taurus)
CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
NLK phosphorylates TCF/LEF (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
p-TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Beta-catenin translocates to the nucleus (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
Deactivation of the beta-catenin transactivating complex (Bos taurus)
AKT phosphorylates CBY1 (Bos taurus)
CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
pS20-CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
Beta-catenin binds SOX proteins (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
CBY1 binds beta-catenin (Bos taurus)
CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1:CHD8 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
CTNNBIP1 binds beta-catenin (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
CTNNBIP1:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF:Beta-catenin binds SOX proteins (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:SOX4,SOX13,SOX17 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
XPO1 binds the beta-catenin:CBY complex (Bos taurus)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
YWHAZ:p-S20-CBY:CTNNB1 [nucleoplasm] (Bos taurus)
pS20-CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
YWHAZ:p-S20-CBY:CTNNB1 [nucleoplasm] (Bos taurus)
pS20-CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Bos taurus)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
YWHAZ:p-S20-CBY:CTNNB1 [nucleoplasm] (Bos taurus)
pS20-CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
YWHAZ binds p-CBY:CTNNB1 (Bos taurus)
YWHAZ:p-S20-CBY:CTNNB1 [nucleoplasm] (Bos taurus)
pS20-CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
pS20-CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
beta-catenin is replaced by repression complexes at the promoter (Bos taurus)
APC:CTBP:CTNNB1:BTRC [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
Formation of the beta-catenin:TCF transactivating complex (Bos taurus)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
Beta-catenin recruits CBP/p300 (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
Beta-catenin recruits CDC73 and LEO1 (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
Beta-catenin recruits SMARCA4 (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:SMARCA4:TERT [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
Beta-catenin recruits TRRAP/KAT5 HAT components (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
Beta-catenin:TCF associates with BCL9 and PYGO (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
Recruitment of SET1 methyltransferase complex (Bos taurus)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
SET1 complex trimethylates H3K4 at the MYC gene (Bos taurus)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Bos taurus)
CTNNB1 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:Q0VCX4
Gene Names
CTNNB1
Reference Genes
BioGPS Gene:539003 CTNNB1
ENSEMBL:ENSBTAG00000016420
KEGG Gene (Bos taurus):539003 CTNNB1
Monarch:539003 CTNNB1
NCBI Gene:539003 CTNNB1
Reference Transcript
RefSeq:XM_005222525.3 CTNNB1
RefSeq:NM_001076141.1 CTNNB1
RefSeq:XM_005222523.3 CTNNB1
RefSeq:XM_005222524.3 CTNNB1
Other Identifiers
GO:0000122
GO:0000165
GO:0000209
GO:0000278
GO:0000578
GO:0000791
GO:0000902
GO:0000922
GO:0001221
GO:0001222
GO:0001501
GO:0001569
GO:0001570
GO:0001649
GO:0001658
GO:0001701
GO:0001702
GO:0001706
GO:0001708
GO:0001711
GO:0001764
GO:0001822
GO:0001840
GO:0001894
GO:0001944
GO:0002052
GO:0002053
GO:0002062
GO:0002067
GO:0002089
GO:0002376
GO:0003151
GO:0003266
GO:0003338
GO:0003340
GO:0003682
GO:0003713
GO:0005102
GO:0005515
GO:0005634
GO:0005667
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005912
GO:0005916
GO:0005923
GO:0005938
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006790
GO:0007010
GO:0007155
GO:0007160
GO:0007268
GO:0007398
GO:0007399
GO:0007403
GO:0007405
GO:0007507
GO:0008104
GO:0008283
GO:0008284
GO:0008285
GO:0008543
GO:0009410
GO:0009948
GO:0009950
GO:0009953
GO:0009954
GO:0010463
GO:0010467
GO:0010468
GO:0010628
GO:0010629
GO:0010718
GO:0010909
GO:0012501
GO:0014704
GO:0016020
GO:0016055
GO:0016192
GO:0016323
GO:0016327
GO:0016328
GO:0016331
GO:0016342
GO:0016525
GO:0016600
GO:0016922
GO:0019899
GO:0019900
GO:0019901
GO:0019903
GO:0021819
GO:0021854
GO:0022009
GO:0022405
GO:0022414
GO:0023052
GO:0030018
GO:0030027
GO:0030054
GO:0030097
GO:0030154
GO:0030163
GO:0030182
GO:0030217
GO:0030316
GO:0030324
GO:0030331
GO:0030539
GO:0030856
GO:0030858
GO:0030877
GO:0030900
GO:0030901
GO:0030902
GO:0030997
GO:0031016
GO:0031069
GO:0031253
GO:0031396
GO:0031528
GO:0031641
GO:0032200
GO:0032212
GO:0032331
GO:0032355
GO:0032968
GO:0032991
GO:0032993
GO:0033077
GO:0033234
GO:0034330
GO:0034332
GO:0034333
GO:0034394
GO:0034750
GO:0035050
GO:0035112
GO:0035115
GO:0035116
GO:0036023
GO:0036211
GO:0036520
GO:0042127
GO:0042129
GO:0042475
GO:0042733
GO:0042734
GO:0042981
GO:0042995
GO:0043065
GO:0043066
GO:0043161
GO:0043226
GO:0043231
GO:0043296
GO:0043410
GO:0043524
GO:0043525
GO:0043588
GO:0044325
GO:0044338
GO:0045177
GO:0045202
GO:0045211
GO:0045294
GO:0045296
GO:0045453
GO:0045595
GO:0045596
GO:0045603
GO:0045667
GO:0045669
GO:0045670
GO:0045671
GO:0045743
GO:0045892
GO:0045893
GO:0045944
GO:0045976
GO:0046332
GO:0048469
GO:0048471
GO:0048489
GO:0048513
GO:0048538
GO:0048568
GO:0048599
GO:0048617
GO:0048643
GO:0048660
GO:0048664
GO:0048709
GO:0048715
GO:0048856
GO:0048870
GO:0050768
GO:0050808
GO:0051145
GO:0051450
GO:0051884
GO:0051963
GO:0060066
GO:0060070
GO:0060173
GO:0060439
GO:0060440
GO:0060441
GO:0060479
GO:0060484
GO:0060487
GO:0060492
GO:0060742
GO:0060767
GO:0060769
GO:0060789
GO:0060856
GO:0060916
GO:0061047
GO:0061154
GO:0061198
GO:0061549
GO:0061550
GO:0061629
GO:0070161
GO:0070369
GO:0070411
GO:0070602
GO:0071363
GO:0071681
GO:0071944
GO:0072033
GO:0072053
GO:0072054
GO:0072079
GO:0072089
GO:0072182
GO:0072497
GO:0090090
GO:0090279
GO:0090425
GO:0090575
GO:0097091
GO:0097190
GO:0097718
GO:0098609
GO:0098685
GO:0098831
GO:0098978
GO:0099092
GO:0140110
GO:0140297
GO:1901135
GO:1901331
GO:1903377
GO:1904888
GO:1904948
GO:1990138
GO:1990226
GO:1990403
GO:1990711
GO:1990791
GO:1990907
GO:1990909
GO:1990963
GO:2000008
GO:2000017
GO:2000179
GO:2000288
GO:2000648
GO:2001234
Participates
as a component of
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNBIP1:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1:CHD8 [nucleoplasm] (Bos taurus)
CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Bos taurus)
CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
pS20-CBY1:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Bos taurus)
APC:CTBP:CTNNB1:BTRC [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Bos taurus)
p-TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Bos taurus)
TCF7L1/TCF7L2/LEF1:CTNNB1 [nucleoplasm] (Bos taurus)
TCF/LEF:CTNNB1 [nucleoplasm] (Bos taurus)
as an input of
CTNNBIP1 binds beta-catenin (Bos taurus)
CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Bos taurus)
Beta-catenin binds SOX proteins (Bos taurus)
CBY1 binds beta-catenin (Bos taurus)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Bos taurus)
as an output of
Beta-catenin translocates to the nucleus (Bos taurus)
Other forms of this molecule
phospho-CTNNB1 [nucleoplasm]
phospho-CTNNB1 [cytosol]
CTNNB1 [plasma membrane]
phospho-CTNNB1 [cytosol]
phospho-CTNNB1 [cytosol]
phospho-CTNNB1 [cytosol]
phospho-CTNNB1 [cytosol]
CTNNB1 [cytosol]
CTNNB1 [cytosol]
CTNNB1 [cytosol]
Inferred From
CTNNB1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001069609.1
,
XP_005222580.1
,
XP_005222581.1
,
XP_005222582.1
OpenTargets
ENSG00000168036
Ensembl
ENSBTAP00000021838
,
ENSBTAT00000021838
,
ENSBTAG00000016420
VGNC
27802
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