Reactome | DLG1 [plasma membrane]

DLG1 [plasma membrane]

Stable Identifier

R-BTA-375977

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

DLG1, A0A3Q1MFJ1

Locations in the PathwayBrowser

Expand all

Neuronal System (Bos taurus)

- Protein-protein interactions at synapses (Bos taurus)
  - Synaptic adhesion-like molecules (Bos taurus)
    - SALMs 1-3 bind to PSD-95 family members (Bos taurus)
      - PSD-95 family [plasma membrane] (Bos taurus)
        
        DLG1 [plasma membrane] (Bos taurus)
      - SALMs 1-3:PSD-95 family [plasma membrane] (Bos taurus)
        
        PSD-95 family [plasma membrane] (Bos taurus)
        
        DLG1 [plasma membrane] (Bos taurus)
- Transmission across Chemical Synapses (Bos taurus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
    - Activation of NMDA receptors and postsynaptic events (Bos taurus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Bos taurus)
        
        Ca2+ influx into the post-synaptic cell (Bos taurus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Bos taurus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Bos taurus)
        
        DLG1 homotetramer [plasma membrane] (Bos taurus)
        
        DLG1 [plasma membrane] (Bos taurus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Bos taurus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Bos taurus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Bos taurus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Bos taurus)
        
        DLG1 homotetramer [plasma membrane] (Bos taurus)
        
        DLG1 [plasma membrane] (Bos taurus)
    - Activation of kainate receptors upon glutamate binding (Bos taurus)
      - Ionotropic activity of kainate receptors (Bos taurus)
        
        Activation of Ca-permeable Kainate Receptor (Bos taurus)
        
        Activation of Ca-permeable Kainate receptors (Bos taurus)
        
        Kainate receptor-glutamate complex [plasma membrane] (Bos taurus)
        
        Kainate Receptors [plasma membrane] (Bos taurus)
        
        GRIK 2 homomer [plasma membrane] (Bos taurus)
        
        GRIK2 interacting proteins [plasma membrane] (Bos taurus)
        
        DLG1 [plasma membrane] (Bos taurus)
        
        kainate receptor binds glutamate (Bos taurus)
        
        Kainate Receptors [plasma membrane] (Bos taurus)
        
        GRIK 2 homomer [plasma membrane] (Bos taurus)
        
        GRIK2 interacting proteins [plasma membrane] (Bos taurus)
        
        DLG1 [plasma membrane] (Bos taurus)
        
        Kainate receptor-glutamate complex [plasma membrane] (Bos taurus)
        
        Kainate Receptors [plasma membrane] (Bos taurus)
        
        GRIK 2 homomer [plasma membrane] (Bos taurus)
        
        GRIK2 interacting proteins [plasma membrane] (Bos taurus)
        
        DLG1 [plasma membrane] (Bos taurus)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Bos taurus)
      - Trafficking of AMPA receptors (Bos taurus)
        
        Trafficking of GluR1-containing AMPA receptors (Bos taurus)
        
        DLG1 [plasma membrane] (Bos taurus)

Signal Transduction (Bos taurus)

- MAPK family signaling cascades (Bos taurus)
  - MAPK1/MAPK3 signaling (Bos taurus)
    - RAF/MAP kinase cascade (Bos taurus)
      - RAS GEFs promote RAS nucleotide exchange (Bos taurus)
        
        RAS GEFs [plasma membrane] (Bos taurus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Bos taurus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Bos taurus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Bos taurus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Bos taurus)
        
        DLG1 homotetramer [plasma membrane] (Bos taurus)
        
        DLG1 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1MFJ1

Gene Names

DLG1

Reference Genes

ENSEMBL:ENSBTAG00000020378.6

Other Identifiers

785291

GO:0005515

GO:0005886

GO:0005923

GO:0007155

GO:0007163

GO:0007268

GO:0016020

GO:0016323

GO:0019900

GO:0023052

GO:0031594

GO:0043005

GO:0043113

GO:0043226

GO:0045197

GO:0098609

GO:0098839

GO:0099645

GO:0110165

Participates

as a member of

PSD-95 family [plasma membrane] (Bos taurus)

as a component of

as an output of

Trafficking of GluR1-containing AMPA receptors (Bos taurus)

Other forms of this molecule

DLG1 [cytosol]

Inferred From

DLG1 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000075711

Ensembl

ENSBTAP00000067717, ENSBTAG00000020378, ENSBTAT00000077778

VGNC

53531

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