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active PDGF-AA dimer [extracellular region]
Stable Identifier
R-BTA-380761
Type
Complex
Species
Bos taurus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
Exocytosis of platelet alpha granule contents (Bos taurus)
Platelet alpha granule contents [extracellular region] (Bos taurus)
PDGF dimer [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by PDGF (Bos taurus)
Autophosphorylation of PDGF alpha receptors (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
Downstream signal transduction (Bos taurus)
Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
Activation of Src (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
Crk binds to the active PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
GRB2:SOS1 complex binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
Grb7 binds to the active PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
Nck binds to the active PDGF receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PI3-kinase binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PLC-gamma binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
Phosphorylation of PLCgamma by PDGFR (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
SH2 domain of Src binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
SHP2 binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
STAT binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
p130Cas and C3G bind PDGFR bound Crk (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF dimer binds two receptors simultaneously (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF:PDGF receptor dimer [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGF-AA clevage by Furin (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFRs bind type I TKI (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Bos taurus)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
active PDGF-AA dimer [extracellular region] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
PDGFA [extracellular region]
(Bos taurus)
Participates
as a member of
PDGF dimer [extracellular region] (Bos taurus)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Bos taurus)
as an output of
PDGF-AA clevage by Furin (Bos taurus)
Inferred From
PDGF A homodimer [extracellular region]
(Homo sapiens)
active PDGF-AA dimer [extracellular region]
(Homo sapiens)
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