Reactome | PIK3CD [plasma membrane]

PIK3CD [plasma membrane]

Stable Identifier

R-BTA-392274

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

PIK3CD, E1BE66

Locations in the PathwayBrowser

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Developmental Biology (Bos taurus)

- Nervous system development (Bos taurus)
  - Axon guidance (Bos taurus)
    - RET signaling (Bos taurus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)

Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Regulation of T cell activation by CD28 family (Bos taurus)
    - Co-stimulation by CD28 (Bos taurus)
      - CD28 dependent PI3K/Akt signaling (Bos taurus)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
        
        CD28:PI3K [plasma membrane] (Bos taurus)
        
        Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        PI3K binds CD28 (Bos taurus)
        
        CD28:PI3K [plasma membrane] (Bos taurus)
        
        Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
    - Co-stimulation by ICOS (Bos taurus)
      - PI3K binds ICOS (Bos taurus)
        
        Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        ICOS:PI3K [plasma membrane] (Bos taurus)
        
        Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
  - Signaling by the B Cell Receptor (BCR) (Bos taurus)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
      - BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
        
        BCAP Signalosome [plasma membrane] (Bos taurus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
      - CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)
        
        CD19 Signalosome [plasma membrane] (Bos taurus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
      - p-CD19:VAV binds PI3K and GRB2 (Bos taurus)
        
        CD19 Signalosome [plasma membrane] (Bos taurus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
- Cytokine Signaling in Immune system (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-2 family signaling (Bos taurus)
      - Interleukin receptor SHC signaling (Bos taurus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
      - 14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
      - Interleukin receptor SHC signaling (Bos taurus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
      - Regulation of signaling by CBL (Bos taurus)
        
        CBL ubiquitinates PI3K (Bos taurus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        K63polyUb-PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)

Signal Transduction (Bos taurus)

- Intracellular signaling by second messengers (Bos taurus)
  - PIP3 activates AKT signaling (Bos taurus)
    - Negative regulation of the PI3K/AKT network (Bos taurus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
        
        PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
        
        Activator:PI3K [plasma membrane] (Bos taurus)
        
        BCAP Signalosome [plasma membrane] (Bos taurus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        CD19 Signalosome [plasma membrane] (Bos taurus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        CD28:PI3K [plasma membrane] (Bos taurus)
        
        Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        ICOS:PI3K [plasma membrane] (Bos taurus)
        
        Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
    - PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
      - Activator:PI3K [plasma membrane] (Bos taurus)
        
        BCAP Signalosome [plasma membrane] (Bos taurus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        CD19 Signalosome [plasma membrane] (Bos taurus)
        
        PIK3CD:PIK3R1 [plasma membrane] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        CD28:PI3K [plasma membrane] (Bos taurus)
        
        Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)
        
        ICOS:PI3K [plasma membrane] (Bos taurus)
        
        Class 1A PI3Ks [cytosol] (Bos taurus)
        
        PI3K delta [cytosol] (Bos taurus)
        
        PIK3CD [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:E1BE66

Gene Names

PIK3CD

Reference Genes

BioGPS Gene:504531 PIK3CD

ENSEMBL:ENSBTAG00000018984.5

Monarch:504531 PIK3CD

NCBI Gene:504531 PIK3CD

UCSC:E1BE66 PIK3CD

Reference Transcript

RefSeq:XM_010813246.1 PIK3CD

Other Identifiers

504531

GO:0001938

GO:0003824

GO:0005943

GO:0010595

GO:0010628

GO:0016301

GO:0016740

GO:0030335

GO:0033031

GO:0038084

GO:0043491

GO:1905278

Participates

as a component of

Other forms of this molecule

PIK3CD [cytosol]

Inferred From

PIK3CD [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_010811548.1

ENSEMBL

ENSBTAT00000025274, ENSBTAP00000025274, ENSBTAG00000018984

VGNC

32891

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