Reactome | ARPC1B [cytosol]

ARPC1B [cytosol]

Stable Identifier

R-BTA-419960

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

Actin-related protein 2/3 complex subunit 1B, ARC1B_BOVIN, ARPC1B

Locations in the PathwayBrowser

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Developmental Biology (Bos taurus)

- Nervous system development (Bos taurus)
  - Axon guidance (Bos taurus)
    - EPH-Ephrin signaling (Bos taurus)
      - EPHB-mediated forward signaling (Bos taurus)
        
        N-WASP binds ARP2/3 and G-actin (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ARPC1B [cytosol] (Bos taurus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ARPC1B [cytosol] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
  - Signaling by Rho GTPases (Bos taurus)
    - RHO GTPase Effectors (Bos taurus)
      - RHO GTPases Activate WASPs and WAVEs (Bos taurus)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)
        
        Mother filament:branching complex [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ARPC1B [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ARPC1B [cytosol] (Bos taurus)
        
        Branching and elongation of mother and daughter filaments (Bos taurus)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ARPC1B [cytosol] (Bos taurus)
        
        Mother filament:branching complex:daughter filament [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ARPC1B [cytosol] (Bos taurus)
        
        Detachment of WASP/WAVE (Bos taurus)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ARPC1B [cytosol] (Bos taurus)
        
        Mother filament:branching complex [cytosol] (Bos taurus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Bos taurus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Bos taurus)
        
        ARPC1B [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q58CQ2 ARPC1B

Gene Names

ARPC1B

Chain

chain:1-372

Reference Genes

BioGPS Gene:326600 ARPC1B

ENSEMBL:ENSBTAG00000046248.2 ARPC1B

KEGG Gene (Bos taurus):326600 ARPC1B

Monarch:326600 ARPC1B

NCBI Gene:326600 ARPC1B

Reference Transcript

RefSeq:NM_001014844.3 ARPC1B

Other Identifiers

326600

GO:0003779

GO:0005198

GO:0005200

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005885

GO:0007010

GO:0008092

GO:0015629

GO:0034314

GO:0043226

GO:0051015

Participates

as a component of

Inferred From

ARPC1B [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001014844.1

OpenTargets

ENSG00000130429

Ensembl

ENSBTAP00000056302, ENSBTAT00000064158, ENSBTAG00000046248

VGNC

26164

PDB

2P9L, 3RSE, 4JD2, 2P9S, 1K8K, 4XF2, 2P9U, 3UKR, 1U2V, 7TPT, 6DEC, 3UKU, 1TYQ, 2P9I, 2P9N, 3DXK, 2P9P, 7JPN, 3DXM, 4XEI, 3ULE, 2P9K

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