Reactome | JUN [nucleoplasm]

JUN [nucleoplasm]

Stable Identifier

R-BTA-450250

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

JUN, Q08DH1

Locations in the PathwayBrowser

Expand all

Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-17 signaling (Bos taurus)
      - MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        Activation of the AP-1 family of transcription factors (Bos taurus)
        
        Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)
- Innate Immune System (Bos taurus)
  - Fc epsilon receptor (FCERI) signaling (Bos taurus)
    - FCERI mediated MAPK activation (Bos taurus)
      - Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)
  - Toll-like Receptor Cascades (Bos taurus)
    - Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
      - MyD88 cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        Activation of the AP-1 family of transcription factors (Bos taurus)
        
        Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        Activation of the AP-1 family of transcription factors (Bos taurus)
        
        Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        Activation of the AP-1 family of transcription factors (Bos taurus)
        
        Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
      - MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        Activation of the AP-1 family of transcription factors (Bos taurus)
        
        Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
      - MyD88-independent TLR4 cascade (Bos taurus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        Activation of the AP-1 family of transcription factors (Bos taurus)
        
        Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        Activation of the AP-1 family of transcription factors (Bos taurus)
        
        Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
      - MyD88 cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        Activation of the AP-1 family of transcription factors (Bos taurus)
        
        Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
      - MyD88 dependent cascade initiated on endosome (Bos taurus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        Activation of the AP-1 family of transcription factors (Bos taurus)
        
        Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)
    - Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
      - MyD88 dependent cascade initiated on endosome (Bos taurus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Bos taurus)
        
        Activation of the AP-1 family of transcription factors (Bos taurus)
        
        Activated JNKs phosphorylate c-JUN (Bos taurus)
        
        JUN [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q08DH1

Gene Names

JUN

Reference Genes

BioGPS Gene:280831 JUN

ENSEMBL:ENSBTAG00000004037.5

KEGG Gene (Bos taurus):280831 JUN

Monarch:280831 JUN

NCBI Gene:280831 JUN

Reference Transcript

RefSeq:NM_001077827.1 JUN

Participates

as an input of

Activated JNKs phosphorylate c-JUN (Bos taurus)

as a component of

FOS:JUN [nucleoplasm] (Bos taurus)

Other forms of this molecule

phospho-JUN [nucleoplasm]

Inferred From

JUN [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001071295.1

OpenTargets

ENSG00000177606

VGNC

30386

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