Reactome | MAPK10 [cytosol]

MAPK10 [cytosol]

Stable Identifier

R-BTA-450352

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

MAPK10, A0A3Q1LRM6

Locations in the PathwayBrowser

Expand all

Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Signaling by Interleukins (Bos taurus)
    - Interleukin-17 signaling (Bos taurus)
      - MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)
- Innate Immune System (Bos taurus)
  - Fc epsilon receptor (FCERI) signaling (Bos taurus)
    - FCERI mediated MAPK activation (Bos taurus)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)
  - Toll-like Receptor Cascades (Bos taurus)
    - Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
      - MyD88 cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)
    - Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)
    - Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
      - MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)
    - Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
      - MyD88-independent TLR4 cascade (Bos taurus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)
    - Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
      - MyD88 cascade initiated on plasma membrane (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
      - MyD88 dependent cascade initiated on endosome (Bos taurus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)
    - Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
      - MyD88 dependent cascade initiated on endosome (Bos taurus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
        
        MAP kinase activation (Bos taurus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Bos taurus)
        
        MAPK8,9,10 [cytosol] (Bos taurus)
        
        MAPK10 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1LRM6

Gene Names

MAPK10

Reference Genes

ENSEMBL:ENSBTAG00000020048.6

Other Identifiers

537631

GO:0000165

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004705

GO:0004707

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0006468

GO:0007254

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0036211

GO:0043226

GO:0048511

GO:0106310

GO:0140096

Participates

as a member of

MAPK8,9,10 [cytosol] (Bos taurus)

Other forms of this molecule

phospho-MAPK10 [cytosol]

phospho-MAPK10 [nucleoplasm]

Inferred From

MAPK10 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000109339

Ensembl

ENSBTAT00000084303, ENSBTAP00000059818, ENSBTAG00000020048

VGNC

31213

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