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APC [cytosol]
Stable Identifier
R-BTA-5246690
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
K63polyUb-APC, A0A3Q1LMC7
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ovarian tumor domain proteases (Bos taurus)
ZRANB1 binds APC (Bos taurus)
APC [cytosol] (Bos taurus)
ZRANB1:K63polyUb-APC [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by WNT (Bos taurus)
Degradation of beta-catenin by the destruction complex (Bos taurus)
AXIN is phosphorylated in the destruction complex (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
Assembly of the destruction complex (Bos taurus)
APC [cytosol] (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
Association of beta-catenin with the destruction complex (Bos taurus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
Beta-catenin phosphorylation cascade (Bos taurus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Bos taurus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Bos taurus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Bos taurus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
Phosphorylation of APC component of the destruction complex (Bos taurus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
ZRANB1 binds APC (Bos taurus)
APC [cytosol] (Bos taurus)
ZRANB1:K63polyUb-APC [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
TCF dependent signaling in response to WNT (Bos taurus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Bos taurus)
Beta-catenin is released from the destruction complex (Bos taurus)
APC [cytosol] (Bos taurus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
APC [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:A0A3Q1LMC7
Gene Names
APC
Reference Genes
ENSEMBL:ENSBTAG00000018852.6
UCSC:A0A3Q1LMC7 APC
Other Identifiers
533233
Bt.19631.1.A1_at
Bt.21483.1.S1_at
Bt.21483.2.A1_at
Bt.29563.1.A1_at
Bt.6907.1.S1_at
GO:0000281
GO:0000776
GO:0000910
GO:0001708
GO:0005515
GO:0005634
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005874
GO:0005881
GO:0005886
GO:0005912
GO:0005923
GO:0006974
GO:0007026
GO:0007094
GO:0007389
GO:0007399
GO:0008013
GO:0008017
GO:0008092
GO:0008285
GO:0008286
GO:0016055
GO:0016328
GO:0016342
GO:0016477
GO:0019887
GO:0019901
GO:0030027
GO:0030178
GO:0030335
GO:0030877
GO:0031274
GO:0031625
GO:0032587
GO:0032886
GO:0043065
GO:0043226
GO:0043231
GO:0045295
GO:0045732
GO:0048471
GO:0048856
GO:0048870
GO:0051010
GO:0051988
GO:0060632
GO:0065003
GO:0070840
GO:0071944
GO:0090090
GO:0098772
GO:1902807
GO:1904781
GO:2000134
Participates
as an input of
ZRANB1 binds APC (Bos taurus)
Assembly of the destruction complex (Bos taurus)
as a component of
ZRANB1:K63polyUb-APC [cytosol] (Bos taurus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Bos taurus)
as an output of
Beta-catenin is released from the destruction complex (Bos taurus)
Other forms of this molecule
phospho-APC [cytosol]
APC [nucleoplasm]
APC [cytosol]
APC [cytosol]
APC [cytosol]
Inferred From
K63polyUb-APC [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ENSEMBL
ENSBTAT00000086393
,
ENSBTAP00000057792
,
ENSBTAG00000018852
VGNC
55103
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