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POLB [nucleoplasm]
Stable Identifier
R-BTA-53845
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
Q27958
Locations in the PathwayBrowser
Expand all
DNA Repair (Bos taurus)
Base Excision Repair (Bos taurus)
Resolution of Abasic Sites (AP sites) (Bos taurus)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Bos taurus)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
NEIL1,NEIL2 recruits POLB to incised AP site (Bos taurus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Bos taurus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Bos taurus)
PCNA-Dependent Long Patch Base Excision Repair (Bos taurus)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Bos taurus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB-Dependent Long Patch Base Excision Repair (Bos taurus)
LIG1 binds POLB at long-patch BER site (Bos taurus)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Bos taurus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
LIG1 bound to POLB ligates SSB (Bos taurus)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Bos taurus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
LIG1:POLB:dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Bos taurus)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Bos taurus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Bos taurus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB-mediated DNA strand displacement synthesis (Bos taurus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
Recruitment of POLB to oxidatively damaged AP site (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
Resolution of AP sites via the single-nucleotide replacement pathway (Bos taurus)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Bos taurus)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
Recruitment of POLB to the AP site (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Bos taurus)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Bos taurus)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
Resynthesis of excised residue by POLB (Bos taurus)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ub-specific processing proteases (Bos taurus)
USP47 deubiquitinates POLB (Bos taurus)
USP47:POLB [nucleoplasm] (Bos taurus)
POLB [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:Q27958
Reference Genes
BioGPS Gene:614688
ENSEMBL:ENSBTAG00000000225
ENSEMBL:ENSBTAG00000000225.6
KEGG Gene (Bos taurus):614688
Monarch:614688
NCBI Gene:614688
Reference Transcript
RefSeq:NM_001034764.1
Other Identifiers
614688
GO:0003677
GO:0003824
GO:0003887
GO:0006281
GO:0016740
GO:0016779
GO:0034061
GO:0140097
Participates
as a component of
USP47:POLB [nucleoplasm] (Bos taurus)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Bos taurus)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Bos taurus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
LIG1:POLB:dsDNA [nucleoplasm] (Bos taurus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Bos taurus)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Bos taurus)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Bos taurus)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Bos taurus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Bos taurus)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Bos taurus)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Bos taurus)
as an input of
Recruitment of POLB to the AP site (Bos taurus)
Recruitment of POLB to oxidatively damaged AP site (Bos taurus)
NEIL1,NEIL2 recruits POLB to incised AP site (Bos taurus)
as an output of
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Bos taurus)
Other forms of this molecule
PolyUb-POLB [nucleoplasm]
Inferred From
POLB [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001029936.1
IntEnz
2.7.7.7
Ensembl
ENSBTAG00000000225
,
ENSBTAP00000000276
,
ENSBTAT00000000276
VGNC
33112
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