Reactome | LAMTOR2 [lysosomal membrane]

LAMTOR2 [lysosomal membrane]

Stable Identifier

R-BTA-5653583

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

lysosomal membrane

Synonyms

LAMTOR2, Q3T132

Locations in the PathwayBrowser

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Autophagy (Bos taurus)

- Macroautophagy (Bos taurus)
  - Active MTORC1 phosphorylates ULK1 (Bos taurus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
  - Rheb in the MTORC1 complex hydrolyses GTP (Bos taurus)
    - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Bos taurus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Bos taurus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)

Cellular responses to stimuli (Bos taurus)

- Cellular responses to stress (Bos taurus)
  - Cellular response to starvation (Bos taurus)
    - Amino acids regulate mTORC1 (Bos taurus)
      - RRAGA,B exchanges GDP for GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - RRAGA,B hydrolyzes GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - RRAGC,D exchanges GTP for GDP (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - RRAGC,D hydrolyzes GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - mTORC1 binds RHEB:GTP (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Bos taurus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional Regulation by TP53 (Bos taurus)
      - TP53 Regulates Metabolic Genes (Bos taurus)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)

Signal Transduction (Bos taurus)

- MTOR signalling (Bos taurus)
  - AKT1S1 (PRAS40) binds mTORC1 (Bos taurus)
    - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Bos taurus)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
  - Formation of active mTORC1 complex (Bos taurus)
    - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Bos taurus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Bos taurus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
  - Ragulator binds Rag dimers (Bos taurus)
    - Ragulator [lysosomal membrane] (Bos taurus)
      - LAMTOR2 [lysosomal membrane] (Bos taurus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
      - Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
  - SLC38A9 binds Ragulator:Rag dimers (Bos taurus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
      - Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
  - SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Bos taurus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
  - mTORC1 phosphorylates AKT1S1 (Bos taurus)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Bos taurus)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Bos taurus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
  - mTORC1-mediated signalling (Bos taurus)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Bos taurus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)
      - Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Bos taurus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Bos taurus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Bos taurus)
        
        Active mTORC1 complex [lysosomal membrane] (Bos taurus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Bos taurus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Bos taurus)
        
        Ragulator [lysosomal membrane] (Bos taurus)
        
        LAMTOR2 [lysosomal membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:Q3T132

Gene Names

LAMTOR2

Reference Genes

BioGPS Gene:616375 LAMTOR2

ENSEMBL:ENSBTAG00000011754

KEGG Gene (Bos taurus):616375 LAMTOR2

Monarch:616375 LAMTOR2

NCBI Gene:616375 LAMTOR2

Reference Transcript

RefSeq:NM_001034791.1 LAMTOR2

Other Identifiers

616375

Bt.868.1.S1_a_at

Bt.868.1.S1_at

GO:0000186

GO:0001558

GO:0003674

GO:0005085

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005770

GO:0006464

GO:0007165

GO:0008150

GO:0010761

GO:0019899

GO:0031410

GO:0032008

GO:0032991

GO:0034330

GO:0034613

GO:0040007

GO:0040011

GO:0043226

GO:0048870

GO:0060090

GO:0071230

GO:0071986

GO:0150116

GO:1902414

Participates

as a component of

Ragulator [lysosomal membrane] (Bos taurus)

Other forms of this molecule

LAMTOR2 [specific granule membrane]

LAMTOR2 [plasma membrane]

LAMTOR2 [tertiary granule membrane]

LAMTOR2 [endosome membrane]

Inferred From

LAMTOR2 [lysosomal membrane] (Homo sapiens)

Cross References

RefSeq

NP_001029963.1

OpenTargets

ENSG00000116586

Ensembl

ENSBTAT00000048084, ENSBTAP00000045185, ENSBTAG00000011754

VGNC

30780

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