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IRS2 [cytosol]
Stable Identifier
R-BTA-57528
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
IRS2, F1MJE0
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
RET signaling (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes:RET interactors [plasma membrane] (Bos taurus)
RET interactors [cytosol] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
RET interactors [cytosol] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-7 signaling (Bos taurus)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Bos taurus)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Bos taurus)
IRS1,2 [cytosol] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
IRS1,2 [cytosol] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Signaling by Erythropoietin (Bos taurus)
EPOR binds EPOR agonists (Bos taurus)
EPOR agonists:EPOR:JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
EPOR:JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
EPOR:JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K bound to EPOR [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
Erythropoietin activates RAS (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS activation (Bos taurus)
Binding of IRS to insulin receptor (Bos taurus)
IRS1,2 [cytosol] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Bos taurus)
IRS1,2 [cytosol] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
Phosphorylation of IRS (Bos taurus)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Bos taurus)
IRS1,2 [cytosol] (Bos taurus)
IRS2 [cytosol] (Bos taurus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Bos taurus)
IRS2 [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:F1MJE0
Gene Names
IRS2
Reference Genes
ENSEMBL:ENSBTAG00000012019.6
Other Identifiers
100300012
GO:0005158
GO:0005829
GO:0005886
GO:0007165
GO:0008286
GO:0023052
GO:0043548
Participates
as a member of
RET interactors [cytosol] (Bos taurus)
IRS1,2 [cytosol] (Bos taurus)
as a component of
EPOR:JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Bos taurus)
as an input of
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Bos taurus)
Other forms of this molecule
IRS2 [plasma membrane]
phospho-IRS2 [cytosol]
phospho-IRS2 [plasma membrane]
Inferred From
IRS2 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000185950
Ensembl
ENSBTAP00000049448
,
ENSBTAG00000012019
,
ENSBTAT00000015938
VGNC
30284
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