Reactome | NDUFA7 [mitochondrial inner membrane]

NDUFA7 [mitochondrial inner membrane]

Stable Identifier

R-BTA-59858

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

mitochondrial inner membrane

Synonyms

NDUFA7, Q05752

Locations in the PathwayBrowser

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Metabolism (Bos taurus)

- Aerobic respiration and respiratory electron transport (Bos taurus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Bos taurus)
    - Respiratory electron transport (Bos taurus)
      - Complex I biogenesis (Bos taurus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Bos taurus)
        
        980kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Bos taurus)
        
        Complex I [mitochondrial inner membrane] (Bos taurus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Bos taurus)
        
        HP subcomplex [mitochondrial inner membrane] (Bos taurus)
        
        NDUFA7 [mitochondrial inner membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:Q05752

Gene Names

NDUFA7

Reference Genes

BioGPS Gene:338063 NDUFA7

ENSEMBL:ENSBTAG00000052280

ENSEMBL:ENSBTAG00000052280.1 NDUFA7

KEGG Gene (Bos taurus):338063 NDUFA7

Monarch:338063 NDUFA7

NCBI Gene:338063 NDUFA7

Reference Transcript

RefSeq:NM_176658.2 NDUFA7

Other Identifiers

338063

GO:0003735

GO:0003824

GO:0005198

GO:0005739

GO:0005743

GO:0005747

GO:0005761

GO:0005840

GO:0006091

GO:0006120

GO:0016020

GO:0016491

GO:0032543

GO:0042773

GO:0043226

GO:0070469

GO:0140053

Participates

as a component of

HP subcomplex [mitochondrial inner membrane] (Bos taurus)

Inferred From

NDUFA7 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_788831.1

OpenTargets

ENSG00000267855

Ensembl

ENSBTAP00000069350, ENSBTAG00000052280, ENSBTAT00000077911

PDB

7R4C, 7QSL, 7R42, 7R43, 7DGZ, 7R4D, 7R4F, 7QSM, 7DH0, 7R44, 7R4G, 7DGS, 7QSN, 7R45, 7QSO, 7R46, 7DGR, 7DKF, 7R47, 7DGQ, 5O31, 7QSD, 7R48, 7QSK, 7R41

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