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VWF [extracellular region]
Stable Identifier
R-BTA-67271
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
extracellular region
Synonyms
VWF(23-763), F1N0R5
Locations in the PathwayBrowser
Expand all
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GP1b-IX-V activation signalling (Bos taurus)
GP1b signaling involves c-Src (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GP1b-IX-V binds 14-3-3-zeta (Bos taurus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GP1b-IX-V binds filamin (Bos taurus)
GPIb-IX-V:vWF:filamin-A [plasma membrane] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Bos taurus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Bos taurus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GPIb-IX-V binds to vWF:Collagen complex (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
vWF binds to collagen (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Thrombin binding to GP1b:IX:V (Bos taurus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Bos taurus)
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
Exocytosis of platelet alpha granule contents (Bos taurus)
Platelet alpha granule contents [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Autophosphorylation of SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Recruitment of GRB2 to p-PTK2 (Bos taurus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Phosphorylation of pPTK2 by SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Release of CSK from SRC (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
SYK activation by SRC (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
SYK binds to integrin alphaIIb beta3 (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Translocation of PTK2 to Focal complexes (Bos taurus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
Crk binding to p130cas (Bos taurus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Recruitment of BCAR1 to PTK2 complex (Bos taurus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Bos taurus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dissociation of RAS:RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
MAP2Ks and MAPKs bind to the activated RAF complex (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Bos taurus)
RAF/MAPK scaffolds [cytosol] (Bos taurus)
Focal Adhesion/Focal contacts [plasma membrane] (Bos taurus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Bos taurus)
Focal complex [plasma membrane] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
VWF [extracellular region] (Bos taurus)
External Reference Information
External Reference
UniProt:F1N0R5
Gene Names
VWF
Reference Genes
ENSEMBL:ENSBTAG00000012265.6
Other Identifiers
280958
GO:0005515
GO:0005518
GO:0005576
GO:0005615
GO:0007155
GO:0007596
GO:0007599
GO:0030168
GO:0030312
GO:0031012
GO:0031410
GO:0031589
GO:0033093
GO:0042060
GO:0042802
GO:0043226
GO:0062023
Participates
as a member of
Platelet alpha granule contents [extracellular region] (Bos taurus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Bos taurus)
as an input of
vWF binds to collagen (Bos taurus)
as a component of
Collagen type I fibril:vWF [extracellular region] (Bos taurus)
Other forms of this molecule
VWF [platelet alpha granule lumen]
VWF [extracellular region]
VWF [extracellular region]
VWF [extracellular region]
Inferred From
VWF(23-763) [extracellular region]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000110799
Ensembl
ENSBTAT00000016273
,
ENSBTAP00000016273
,
ENSBTAG00000012265
VGNC
36860
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