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XPA [nucleoplasm]
Stable Identifier
R-BTA-67437
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
XPA, Q2TBG4
Locations in the PathwayBrowser
Expand all
DNA Repair (Bos taurus)
Nucleotide Excision Repair (Bos taurus)
Global Genome Nucleotide Excision Repair (GG-NER) (Bos taurus)
Dual Incision in GG-NER (Bos taurus)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Bos taurus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Formation of Incision Complex in GG-NER (Bos taurus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Bos taurus)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Bos taurus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
CHD1L is recruited to GG-NER site (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Formation of the pre-incision complex in GG-NER (Bos taurus)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
RNF111 ubiquitinates SUMOylated XPC (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Recruitment of XPA and release of CAK (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
SUMOylation of XPC (Bos taurus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Bos taurus)
Dual incision in TC-NER (Bos taurus)
3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Bos taurus)
TC-NER incision complex [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Bos taurus)
TC-NER incision complex [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Bos taurus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
ERCC5 and RPA bind TC-NER site (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Formation of TC-NER Pre-Incision Complex (Bos taurus)
Assembly of the pre-incision complex in TC-NER (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)
TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
XPA [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:Q2TBG4
Gene Names
XPA
Reference Genes
BioGPS Gene:537958 XPA
ENSEMBL:ENSBTAG00000009734.4
KEGG Gene (Bos taurus):537958 XPA
Monarch:537958 XPA
NCBI Gene:537958 XPA
Reference Transcript
RefSeq:NM_001038681.2 XPA
Other Identifiers
537958
GO:0000110
GO:0000228
GO:0000715
GO:0003677
GO:0003684
GO:0005634
GO:0005654
GO:0005662
GO:0005694
GO:0006281
GO:0006284
GO:0006289
GO:0006974
GO:0009650
GO:0019904
GO:0034504
GO:0042803
GO:0043226
GO:0045171
GO:0046872
GO:0070914
GO:1901255
GO:1990837
Participates
as an output of
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Bos taurus)
3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)
as an input of
Recruitment of XPA and release of CAK (Bos taurus)
Assembly of the pre-incision complex in TC-NER (Bos taurus)
as a component of
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
Inferred From
XPA [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001033770.1
OpenTargets
ENSG00000136936
Ensembl
ENSBTAP00000012834
,
ENSBTAG00000009734
,
ENSBTAT00000012834
VGNC
36992
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