Reactome | XPA [nucleoplasm]

XPA [nucleoplasm]

Stable Identifier

R-BTA-67437

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

XPA, Q2TBG4

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q2TBG4

Gene Names

XPA

Reference Genes

BioGPS Gene:537958 XPA

ENSEMBL:ENSBTAG00000009734.4

KEGG:bta:537958 XPA

Monarch:537958 XPA

NCBI Gene:537958 XPA

UCSC:Q2TBG4 XPA

Reference Transcript

RefSeq:NM_001038681.2 XPA

Other Identifiers

537958

GO:0000110

GO:0000715

GO:0003677

GO:0003684

GO:0005634

GO:0005654

GO:0005662

GO:0006281

GO:0006284

GO:0006289

GO:0009650

GO:0019904

GO:0034504

GO:0042803

GO:0043226

GO:0045171

GO:0046872

GO:0070914

GO:1901255

GO:1990837

Participates

as an input of

Assembly of the pre-incision complex in TC-NER (Bos taurus)
Recruitment of XPA and release of CAK (Bos taurus)

as a component of

Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex [nucleoplasm] (Bos taurus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Bos taurus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Bos taurus)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Bos taurus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Bos taurus)

as an output of

3' incision by ERCC5 (XPG) in TC-NER (Bos taurus)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Bos taurus)

Inferred From

XPA [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001033770.1

ENSEMBL

ENSBTAT00000130026, ENSBTAP00000093529

VGNC

36992