Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDK2 [nucleoplasm]
Stable Identifier
R-BTA-68365
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
nucleoplasm
Synonyms
CDK2, Q5E9Y0
Locations in the PathwayBrowser
Expand all
Cell Cycle (Bos taurus)
Cell Cycle Checkpoints (Bos taurus)
G1/S DNA Damage Checkpoints (Bos taurus)
p53-Dependent G1/S DNA damage checkpoint (Bos taurus)
p53-Dependent G1 DNA Damage Response (Bos taurus)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
G2/M Checkpoints (Bos taurus)
Activation of ATR in response to replication stress (Bos taurus)
Activation of claspin (Bos taurus)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Loading of claspin onto DNA during replication origin firing (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
Mitotic G1 phase and G1/S transition (Bos taurus)
G0 and Early G1 (Bos taurus)
p107 (RBL1) binds CyclinE/A:CDK2 (Bos taurus)
Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
RBL1:Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)
Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
RBL1:E2F4:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
p130 (RBL2) binds Cyclin E/A:CDK2 (Bos taurus)
Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
RBL2:Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)
Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
G1/S Transition (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cdc45 associates with the pre-replicative complex at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
DNA polymerase alpha:primase binds at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
DNA polymerase epsilon binds at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin E associated events during G1/S transition (Bos taurus)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Translocation of Cyclin E:Cdk2 complex to the nucleus (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
S Phase (Bos taurus)
Cyclin A:Cdk2-associated events at S phase entry (Bos taurus)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Bos taurus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin A:Cdk2:phospho-p27/p21 complex [nucleoplasm] (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Translocation of Cyclin A:Cdk2 complexes to the nucleus (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular Senescence (Bos taurus)
DNA Damage/Telomere Stress Induced Senescence (Bos taurus)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Senescence-Associated Secretory Phenotype (SASP) (Bos taurus)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Bos taurus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
DNA Replication (Bos taurus)
DNA Replication Pre-Initiation (Bos taurus)
Activation of the pre-replicative complex (Bos taurus)
CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cdc45 associates with the pre-replicative complex at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
DNA polymerase alpha:primase binds at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
DNA polymerase epsilon binds at the origin (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Bos taurus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Transcription of Cell Cycle Genes (Bos taurus)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Bos taurus)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CDK2 [nucleoplasm] (Bos taurus)
External Reference Information
External Reference
UniProt:Q5E9Y0
Gene Names
CDK2
Reference Genes
BioGPS Gene:519217 CDK2
ENSEMBL:ENSBTAG00000004021
KEGG:bta:519217 CDK2
Monarch:519217 CDK2
NCBI Gene:519217 CDK2
UCSC:Q5E9Y0 CDK2
Reference Transcript
RefSeq:NM_001014934.1 CDK2
Other Identifiers
519217
Bt.21444.1.S1_at
GO:0000082
GO:0000122
GO:0000287
GO:0000307
GO:0000781
GO:0000793
GO:0000805
GO:0000806
GO:0001673
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005768
GO:0005813
GO:0005815
GO:0005856
GO:0006281
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006468
GO:0006813
GO:0007099
GO:0007165
GO:0007265
GO:0008284
GO:0010389
GO:0010468
GO:0015030
GO:0016301
GO:0016740
GO:0019904
GO:0022414
GO:0030332
GO:0031410
GO:0031453
GO:0032200
GO:0032298
GO:0035173
GO:0043226
GO:0043247
GO:0043687
GO:0045893
GO:0046872
GO:0051301
GO:0051321
GO:0051726
GO:0097123
GO:0097124
GO:0097134
GO:0097135
GO:0097472
GO:0106310
GO:0140096
Participates
as a component of
Cyclin E/A:CDK2 [nucleoplasm] (Bos taurus)
CCNE:CDK2 [nucleoplasm] (Bos taurus)
CCNA:CDK2 [nucleoplasm] (Bos taurus)
CDK [nucleoplasm] (Bos taurus)
Other forms of this molecule
phospho-CDK2 [nucleoplasm]
phospho-CDK2 [nucleoplasm]
CDK2 [cytosol]
phospho-CDK2 [nucleoplasm]
Inferred From
CDK2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001014934.1
ENSEMBL
ENSBTAT00000005252
,
ENSBTAP00000005252
,
ENSBTAG00000004021
VGNC
27123
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text