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What is Reactome ?
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MDP:NOD2 oligomer [cytosol]
Stable Identifier
R-BTA-708350
Type
Complex
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-17 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Bos taurus)
NOD1/2 Signaling Pathway (Bos taurus)
Activated NOD oligomer recruites RIP2 (RICK) (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Activated NOD2 oligomerizes (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
CYLD deubiquitinates NEMO (Bos taurus)
PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
K63 polyubiquitinated RIP2 associates with the TAK1 complex (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
RIP2 binds NEMO (Bos taurus)
PAMP:NOD oligomer:RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
RIP2 is K63 polyubiquitinated (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
TAK1 is activated (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
MAP kinase activation (Bos taurus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Bos taurus)
Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
activated TAK1 mediates p38 MAPK activation (Bos taurus)
activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)
Activated TAK complexes [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Deubiquitination (Bos taurus)
Ovarian tumor domain proteases (Bos taurus)
TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Bos taurus)
PAMP:NOD oligomer:RIP2 [cytosol] (Bos taurus)
MDP:NOD2 oligomer [cytosol] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 6
MDP:NOD2 [cytosol]
(Bos taurus)
Participates
as an input of
Activated NOD oligomer recruites RIP2 (RICK) (Bos taurus)
as an output of
Activated NOD2 oligomerizes (Bos taurus)
as a component of
PAMP:NOD oligomer:RIP2 [cytosol] (Bos taurus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Bos taurus)
Inferred From
PAMP:NOD oligomer [cytosol]
(Homo sapiens)
MDP:NOD2 oligomer [cytosol]
(Homo sapiens)
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