Reactome | RPL10 [cytosol]

RPL10 [cytosol]

Stable Identifier

R-BTA-72402

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

RPL10, Q9XSI3

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Bos taurus)

- Nonsense-Mediated Decay (NMD) (Bos taurus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Bos taurus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10 [cytosol] (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10 [cytosol] (Bos taurus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10 [cytosol] (Bos taurus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10 [cytosol] (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10 [cytosol] (Bos taurus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Bos taurus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10 [cytosol] (Bos taurus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10 [cytosol] (Bos taurus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Bos taurus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10 [cytosol] (Bos taurus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Bos taurus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Bos taurus)
        
        80S ribosome [cytosol] (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10 [cytosol] (Bos taurus)
- rRNA processing (Bos taurus)
  - rRNA processing in the nucleus and cytosol (Bos taurus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Bos taurus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Bos taurus)
        
        60S ribosomal complex [cytosol] (Bos taurus)
        
        RPL10,RPL10L [cytosol] (Bos taurus)
        
        RPL10 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:Q9XSI3

Gene Names

RPL10

Reference Genes

BioGPS Gene:286790 RPL10

ENSEMBL:ENSBTAG00000022275

ENSEMBL:ENSBTAG00000022275.5 RPL10

KEGG Gene (Bos taurus):286790 RPL10

Monarch:286790 RPL10

NCBI Gene:286790 RPL10

Reference Transcript

RefSeq:NM_174760.2 RPL10

Other Identifiers

GO:0000027

GO:0003735

GO:0005198

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0006417

GO:0015934

GO:0022625

GO:0042254

GO:0043226

GO:0045182

GO:0048856

GO:0065003

GO:1990403

GO:1990904

Participates

as a member of

RPL10,RPL10L [cytosol] (Bos taurus)

Inferred From

RPL10 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_777185.1

OpenTargets

ENSG00000147403

Ensembl

ENSBTAG00000022275, ENSBTAT00000020266, ENSBTAP00000020266

Cite Us!