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What is Reactome ?
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PIK3CA [cytosol]
Stable Identifier
R-BTA-74787
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
cytosol
Synonyms
PIK3CA, P32871
Locations in the PathwayBrowser
Expand all
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
RET signaling (Bos taurus)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Hemostasis (Bos taurus)
Cell surface interactions at the vascular wall (Bos taurus)
Tie2 Signaling (Bos taurus)
Interaction of Tie2 and p85 of PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p85 bound to Tie2 [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
GPVI-mediated activation cascade (Bos taurus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)
PI3K alpha, beta, gamma [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Regulation of T cell activation by CD28 family (Bos taurus)
Co-stimulation by CD28 (Bos taurus)
CD28 dependent PI3K/Akt signaling (Bos taurus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K binds CD28 (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Co-stimulation by ICOS (Bos taurus)
PI3K binds ICOS (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K bound to TRAT [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Recruitment of PI3K to plasma membrane (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K bound to TRAT [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Bos taurus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-2 family signaling (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Bos taurus)
14-3-3 zeta binding allows recruitment of PI3K (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Interleukin receptor SHC signaling (Bos taurus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Bos taurus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Regulation of signaling by CBL (Bos taurus)
CBL ubiquitinates PI3K (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
K63polyUb-PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p85-containing Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Innate Immune System (Bos taurus)
DAP12 interactions (Bos taurus)
DAP12 signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Fc epsilon receptor (FCERI) signaling (Bos taurus)
Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
PI3K associates with phosphorylated GAB2 (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Role of phospholipids in phagocytosis (Bos taurus)
PI3K binds to p-6Y-SYK (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K:p-6Y-SYK [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K:p-6Y-SYK [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Phospholipid metabolism (Bos taurus)
PI Metabolism (Bos taurus)
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Bos taurus)
PIK3C(1) [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R2 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R3 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)
PIK3(2) [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R2 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R3 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K bound to TRAT [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
CD28:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
ICOS:PI3K [plasma membrane] (Bos taurus)
Class 1A PI3Ks [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K bound to TRAT [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
RAC1,RAC2,RHOG activate PI3K (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS:GTP binds PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p21 RAS:GTP:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by Erythropoietin (Bos taurus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K bound to EPOR [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Bos taurus)
PI3K alpha, gamma [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (q) signalling events (Bos taurus)
G alpha (q) inhibits PI3K alpha (Bos taurus)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
PI3K binds membrane-associated estrogen receptors (Bos taurus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PTK2 is recruited to methylated ESR1 (Bos taurus)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Bos taurus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
Active ALK recruits PI3K (Bos taurus)
Active ALK:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
Active ALK:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by EGFR (Bos taurus)
GAB1 signalosome (Bos taurus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Bos taurus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by ERBB2 (Bos taurus)
PI3K events in ERBB2 signaling (Bos taurus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Bos taurus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by ERBB4 (Bos taurus)
PI3K events in ERBB4 signaling (Bos taurus)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Bos taurus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Downstream signaling of activated FGFR1 (Bos taurus)
PI-3K cascade:FGFR1 (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by FGFR2 (Bos taurus)
Downstream signaling of activated FGFR2 (Bos taurus)
PI-3K cascade:FGFR2 (Bos taurus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by FGFR3 (Bos taurus)
Downstream signaling of activated FGFR3 (Bos taurus)
PI-3K cascade:FGFR3 (Bos taurus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by FGFR4 (Bos taurus)
Downstream signaling of activated FGFR4 (Bos taurus)
PI-3K cascade:FGFR4 (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Activated FGFR bound to PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by MET (Bos taurus)
MET activates PI3K/AKT signaling (Bos taurus)
MET bound PI3K generates PIP3 (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Phosphorylated GAB1 recruits PI3K to MET (Bos taurus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by NTRKs (Bos taurus)
Signaling by NTRK1 (TRKA) (Bos taurus)
PI3K/AKT activation (Bos taurus)
Active IRS recruits PI3K to the plasma membrane and activates it (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by PDGF (Bos taurus)
Downstream signal transduction (Bos taurus)
PI3-kinase binds to the active receptor (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Bos taurus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by SCF-KIT (Bos taurus)
Direct recruitment of PI3K to p-KIT (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Activated FGFR bound to PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Bos taurus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
p-AXL binds PI3K (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Bos taurus)
PI3K [cytosol] (Bos taurus)
PI3K-catalytic subunit [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Signaling by Rho GTPases (Bos taurus)
RHO GTPase cycle (Bos taurus)
RAC1 GTPase cycle (Bos taurus)
RAC1 binds effectors at the plasma membrane (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Bos taurus)
RAC1 effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
RAC2 GTPase cycle (Bos taurus)
RAC2 binds effectors at the plasma membrane (Bos taurus)
RAC2 plasma membrane effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Bos taurus)
RAC2 plasma membrane effectors [cytosol] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
PIK3CA [cytosol] (Bos taurus)
External Reference Information
External Reference
UniProt:P32871
Gene Names
PIK3CA
Reference Genes
BioGPS Gene:282306 PIK3CA
ENSEMBL:ENSBTAG00000009232
KEGG:bta:282306 PIK3CA
Monarch:282306 PIK3CA
NCBI Gene:282306 PIK3CA
UCSC:P32871 PIK3CA
Reference Transcript
RefSeq:NM_174574.1 PIK3CA
Other Identifiers
282306
GO:0001889
GO:0001932
GO:0003012
GO:0003824
GO:0005942
GO:0005943
GO:0005975
GO:0006006
GO:0006325
GO:0007010
GO:0008286
GO:0010468
GO:0014704
GO:0016301
GO:0016303
GO:0016740
GO:0030027
GO:0030036
GO:0030295
GO:0030835
GO:0032869
GO:0035994
GO:0038084
GO:0040014
GO:0043457
GO:0043491
GO:0043524
GO:0043560
GO:0046934
GO:0048009
GO:0048856
GO:0051897
GO:0055119
GO:0060612
GO:0071333
GO:0071464
GO:0086003
GO:0097009
GO:0098772
GO:0110053
GO:0141068
GO:1905477
GO:2000270
GO:2000811
Participates
as an input of
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Bos taurus)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)
as a component of
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Bos taurus)
K63polyUb-PI3K alpha [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R3 [cytosol] (Bos taurus)
PIK3CA:PIK3R2 [cytosol] (Bos taurus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Bos taurus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
PI3K alpha [cytosol] (Bos taurus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Bos taurus)
PIK3CA:PIK3R1 [cytosol] (Bos taurus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Bos taurus)
as a member of
PI3K-catalytic subunit [cytosol] (Bos taurus)
Inferred From
PIK3CA [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_776999.1
ENSEMBL
ENSBTAT00000072391
,
ENSBTAP00000068953
IntEnz
2.7.1.153
ZINC - Substances
PK3CA_BOVIN
ZINC target
P32871
PRO
P32871
VGNC
32889
ZINC - Predictions - Purchasable
PK3CA_BOVIN
PDB
2V1Y
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:16749 1-PHOSPHATIDYL-1D-MYO-INOSITOL
0.623
8
UniProt:P23727
3
PIK3R1 [cytosol]
(R-BTA-3080572)
PIK3R1 [cytosol]
(R-BTA-74789)
PIK3R1 [plasma membrane]
(R-BTA-198365)
0.524
4
UniProt:P23726
2
PIK3R2 [cytosol]
(R-BTA-3080554)
PIK3R2 [cytosol]
(R-BTA-74791)
0.524
3
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