p-MII:Sag dissociates to p-Rho and Sag

Stable Identifier
R-BTA-74831
Type
Reaction [dissociation]
Species
Bos taurus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
p-MII:Sag dissociates to p-Rho and Sag
The affinity of arrestin (SAG) for phosphorylated opsin declines after all-trans-retinal (atRAL) dissociates and is reduced to all-trans-retinol (atROL) by retinol dehydrogenases. However, arrestin has some affinity even for rhodopsin so it likely releases from some phospho-opsins after 11cRAL has regenerated phosphorylated rhodopsin (Lamb & Pugh 2004, Gurevich & Benovic 1993, Hofmann et al. 1992, Zuang et al. 2013).
Literature References
PubMed ID Title Journal Year
15177205 Dark adaptation and the retinoid cycle of vision

Pugh, EN, Lamb, TD

Prog Retin Eye Res 2004
8505295 Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin

Benovic, JL, Gurevich, VV

J. Biol. Chem. 1993
1386362 The role of arrestin and retinoids in the regeneration pathway of rhodopsin

Van Hooser, P, Pulvermüller, A, Buczyłko, J, Palczewski, K, Hofmann, KP

J. Biol. Chem. 1992
23277586 Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin

Zhuang, T, Vishnivetskiy, SA, Gurevich, VV, Iverson, TM, Sanders, CR, Cho, MK, Chen, Q

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Orthologous Events
Authored
Reviewed
Created
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