Reactome | ZNF143 [nucleoplasm]

ZNF143 [nucleoplasm]

Stable Identifier

R-BTA-83837

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

ZNF143, A6QQW0

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - RNA polymerase II transcribes snRNA genes (Bos taurus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
    - General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Bos taurus)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
    - Integrator complex processes the 3' end of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
    - SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)
      - POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
- RNA Polymerase III Transcription (Bos taurus)
  - RNA Polymerase III Transcription Initiation (Bos taurus)
    - RNA Polymerase III Transcription Initiation From Type 3 Promoter (Bos taurus)
      - Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Bos taurus)
        
        SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Bos taurus)
        
        SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
        
        TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Bos taurus)
        
        SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
      - Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Bos taurus)
        
        RNA Polymerase III:TFIIIB:SNAPc:Type 3 Promoter Complex [nucleoplasm] (Bos taurus)
        
        TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Bos taurus)
        
        SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)
        
        TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Bos taurus)
        
        SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Bos taurus)
        
        ZNF143 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:A6QQW0

Gene Names

ZNF143

Reference Genes

BioGPS Gene:533243 ZNF143

ENSEMBL:ENSBTAG00000016074

ENSEMBL:ENSBTAG00000016074.6 ZNF143

KEGG Gene (Bos taurus):533243 ZNF143

Monarch:533243 ZNF143

NCBI Gene:533243 ZNF143

Reference Transcript

RefSeq:NM_001102154.1 ZNF143

Other Identifiers

533243

GO:0000978

GO:0000981

GO:0003677

GO:0005634

GO:0006351

GO:0006355

GO:0006357

GO:0043226

GO:0046872

GO:0140110

Participates

as an input of

Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Bos taurus)

as a component of

Inferred From

ZNF143 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001095624.1

OpenTargets

ENSG00000166478

Ensembl

ENSBTAG00000016074, ENSBTAT00000064671, ENSBTAP00000054556

VGNC

58348

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