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SOCS-1 and SOCS-3 [cytosol]
Stable Identifier
R-BTA-877267
Type
Set [DefinedSet]
Species
Bos taurus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
Polyubiquitination of substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
Release of E3 from polyubiquitinated substrate (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
E3:Ub:substrate [cytosol] (Bos taurus)
E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Interferon Signaling (Bos taurus)
Interferon alpha/beta signaling (Bos taurus)
Activation of JAK kinases (Bos taurus)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
Interferon gamma signaling (Bos taurus)
Regulation of IFNG signaling (Bos taurus)
SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
Transphosphorylation of JAK1 (Bos taurus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
Signaling by CSF3 (G-CSF) (Bos taurus)
Inactivation of CSF3 (G-CSF) signaling (Bos taurus)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Bos taurus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Bos taurus)
SOCS-1 and SOCS-3 [cytosol] (Bos taurus)
Participants
members
SOCS1 [cytosol]
(Bos taurus)
SOCS3 [cytosol]
(Bos taurus)
Participates
as an output of
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)
as a component of
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Bos taurus)
p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Bos taurus)
RBX1-CUL5-EloB/C-SOCS [cytosol] (Bos taurus)
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Bos taurus)
as an input of
SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)
Inferred From
SOCS-1 and SOCS-3 [cytosol]
(Homo sapiens)
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