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HMGB1 [extracellular region]
Stable Identifier
R-BTA-879382
Type
Protein [EntityWithAccessionedSequence]
Species
Bos taurus
Compartment
extracellular region
Synonyms
HMGB1, P10103
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Innate Immune System (Bos taurus)
Advanced glycosylation endproduct receptor signaling (Bos taurus)
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Bos taurus)
TRAF6 mediated NF-kB activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Neutrophil degranulation (Bos taurus)
Exocytosis of ficolin-rich granule lumen proteins (Bos taurus)
Ficolin-rich granule lumen proteins [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Exocytosis of secretory granule lumen proteins (Bos taurus)
Secretory granule lumen proteins [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF(TICAM1)-mediated TLR4 signaling (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)
AGER ligands:AGER [plasma membrane] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
HMGB1 [extracellular region] (Bos taurus)
External Reference Information
External Reference
UniProt:P10103
Gene Names
HMGB1
Reference Genes
BioGPS Gene:282691 HMGB1
ENSEMBL:ENSBTAG00000018103
KEGG Gene (Bos taurus):282691 HMGB1
Monarch:282691 HMGB1
NCBI Gene:282691 HMGB1
Reference Transcript
RefSeq:NM_176612.1 HMGB1
RefSeq:XM_005213558.1 HMGB1
RefSeq:XM_010810664.2 HMGB1
Other Identifiers
282691
Bt.742.1.S1_at
GO:0003674
GO:0003677
GO:0005575
GO:0005622
GO:0005634
GO:0043226
Participates
as a member of
Secretory granule lumen proteins [extracellular region] (Bos taurus)
Ficolin-rich granule lumen proteins [extracellular region] (Bos taurus)
AGER ligands [extracellular region] (Bos taurus)
Other forms of this molecule
HMGB1 [secretory granule lumen]
HMGB1 [ficolin-1-rich granule lumen]
HMGB1 [nucleoplasm]
HMGB1 [extracellular region]
Inferred From
HMGB1 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_010808966.1
,
NP_788785.1
,
XP_005213615.1
OpenTargets
ENSG00000189403
Ensembl
ENSBTAP00000024094
,
ENSBTAG00000018103
,
ENSBTAT00000024094
VGNC
53816
HMDB Protein
HMDBP13739
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